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NMDA (N-methyl-D-aspartate) receptors are excitatory neurotransmitter receptors in the brain critical for synaptic plasticity and neuronal development. These receptors are Ca2+-permeable glutamate-gated ion channels whose physiological properties are regulated by intracellular Ca2+. We report here the purification of a 20 kDa protein identified as(More)
It has long been recognized that it can be tedious and even infeasible for system administrators to figure out critical security problems residing in full attack graphs, even for small-sized enterprise networks. Therefore a trade-off between analysis accuracy and efficiency needs to be made to achieve a reasonable balance between completeness of the attack(More)
Local Binary Pattern (LBP) has been widely used in texture classification because of its simplicity and computational efficiency. Traditional LBP codes the sign of the local difference and uses the histogram of the binary code to model the given image. However, the directional statistical information is ignored in LBP. In this paper, some directional(More)
We propose a modified alternate direction method for solving convex quadratically constrained quadratic semidefinite optimization problems. The method is a first-order method, therefore requires much less computational effort per iteration than the second-order approaches such as the interior point methods or the smoothing Newton methods. In fact, only a(More)
Ca2+ influx through N-methyl-D-aspartate (NMDA) receptors activates signal transduction pathways critical for many forms of synaptic plasticity in the brain. NMDA receptor-mediated Ca2+ influx also downregulates the gating of NMDA channels through a process called Ca2+-dependent inactivation (CDI). Recent studies have demonstrated that the calcium binding(More)
By using a cre-lox conditional knockout strategy, we report here the generation of androgen receptor knockout (ARKO) mice. Phenotype analysis shows that ARKO male mice have a female-like appearance and body weight. Their testes are 80% smaller and serum testosterone concentrations are lower than in wild-type (wt) mice. Spermatogenesis is arrested at(More)
Infrastructure as a Service (IaaS) cloud has been attracting more and more customers as it provides the highest level of flexibility by offering configurable virtual machines (VMs) and computing infrastructures. Public VM images are usually available for customers to customize and launch. However, the 1 to N mapping between VM images and running instances(More)
Software vulnerabilities represent a major cause of cyber-security problems. The National Vulnerability Database (NVD) is a public data source that maintains standardized information about reported software vulnerabilities. Since its inception in 1997, NVD has published information about more than 43,000 software vulnerabilities affecting more than 17,000(More)
Moving-target defense has been hypothesized as a potential game changer in cyber defense, including that for computer networks. However there has been little work to study how much proac-tively changing a network's configuration can increase the difficulty for attackers and thus improve the resilience of the system under attack. In this paper we present a(More)
—This paper presents a preliminary design for a moving-target defense (MTD) for computer networks to combat an attacker's asymmetric advantage. The MTD system reasons over a set of abstract models that capture the network's configuration and its operational and security goals to select adaptations that maintain the operational integrity of the network. The(More)