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NMDA (N-methyl-D-aspartate) receptors are excitatory neurotransmitter receptors in the brain critical for synaptic plasticity and neuronal development. These receptors are Ca2+-permeable glutamate-gated ion channels whose physiological properties are regulated by intracellular Ca2+. We report here the purification of a 20 kDa protein identified as(More)
Ca2+ influx through N-methyl-D-aspartate (NMDA) receptors activates signal transduction pathways critical for many forms of synaptic plasticity in the brain. NMDA receptor-mediated Ca2+ influx also downregulates the gating of NMDA channels through a process called Ca2+-dependent inactivation (CDI). Recent studies have demonstrated that the calcium binding(More)
Local Binary Pattern (LBP) has been widely used in texture classification because of its simplicity and computational efficiency. Traditional LBP codes the sign of the local difference and uses the histogram of the binary code to model the given image. However, the directional statistical information is ignored in LBP. In this paper, some directional(More)
We propose a modified alternate direction method for solving convex quadratically constrained quadratic semidefinite optimization problems. The method is a first-order method, therefore requires much less computational effort per iteration than the second-order approaches such as the interior point methods or the smoothing Newton methods. In fact, only a(More)
By using a cre-lox conditional knockout strategy, we report here the generation of androgen receptor knockout (ARKO) mice. Phenotype analysis shows that ARKO male mice have a female-like appearance and body weight. Their testes are 80% smaller and serum testosterone concentrations are lower than in wild-type (wt) mice. Spermatogenesis is arrested at(More)
OBJECTIVE To identify the clinical characteristics, pathological changes, and outcome of patients with primary Sjögren's syndrome (pSS). METHODS All patients with pSS and renal involvement who were admitted to Ruijin Hospital from April 1993 to December 2006 were included. All the data of clinical features and pathological changes were retrospectively(More)
Genetic information storage and processing rely on just two polymers, DNA and RNA, yet whether their role reflects evolutionary history or fundamental functional constraints is currently unknown. With the use of polymerase evolution and design, we show that genetic information can be stored in and recovered from six alternative genetic polymers based on(More)
An efficient microwave-assisted transesterification (MAT) technique was developed to prepare biodiesel from yellow horn (Xanthoceras sorbifolia Bunge.) oil with a heteropolyacid (HPA) catalyst namely Cs(2.5)H(0.5)PW(12)O(40). A study for optimizing the reaction conditions such as reaction temperature, time, molar ratio of methanol/oil, catalyst amount, and(More)
This paper presents a novel level set approach to simultaneous tissue segmentation and bias correction of Magnetic Resonance Imaging (MRI) images. We first model the distribution of intensity belonging to each tissue as a Gaussian distribution with spatially varying mean and variance. Then a sliding window is used to transform the intensity domain to(More)
It has long been recognized that it can be tedious and even infeasible for system administrators to figure out critical security problems residing in full attack graphs, even for small-sized enterprise networks. Therefore a trade-off between analysis accuracy and efficiency needs to be made to achieve a reasonable balance between completeness of the attack(More)