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Regulation of Cdx2 expression by promoter methylation, and effects of Cdx2 transfection on morphology and gene expression of human esophageal epithelial cells.
It is suggested that exposure to acid and/or bile acids may activate Cdx2 expression in human esophageal epithelial cells through promoter demethylation, and ectopic Cdx 2 expression in esophagal squamous epithel cells may contribute to intestinal metaplasia of the esophagus. Expand
Inhibition of 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamsters by tea and curcumin.
It is suggested that green tea and curcumin had inhibitory effects against oral carcinogenesis at the post-initiation stage and such inhibition may be related to the suppression of cell proliferation, induction of apoptosis and inhibition of angiogenesis. Expand
Overexpression of 5-Lipoxygenase in Rat and Human Esophageal Adenocarcinoma and Inhibitory Effects of Zileuton and Celecoxib on Carcinogenesis
It is demonstrated that 5-Lox and Cox2 play important roles in the development of EAC through inhibitory effects on esophageal adenocarcinogenesis through inhibition on their respective enzymes of AA metabolism. Expand
Phenotype of columnar-lined esophagus in rats with esophagogastroduodenal anastomosis: similarity to human Barrett's esophagus
- Ying-Chieh Su, Xiaoxin Chen, +4 authors R. Goyal
- Biology, Medicine
- Laboratory Investigation
- 1 June 2004
In rats, EGDA rats may serve as a useful model to study the pathogenesis, molecular biology, and chemopreventive interventions of human BE and EAC. Expand
Overexpression of 5-Lipoxygenase and Cyclooxygenase 2 in Hamster and Human Oral Cancer and Chemopreventive Effects of Zileuton and Celecoxib
It is shown that both 5-Lox and Cox2 played important roles in oral carcinogenesis at the post-initiation stage through their inhibitory effects on arachidonic acid metabolism and combination of inhibitors of both pathways may have synergistic or additive effects of chemoprevention. Expand
Aberrant arachidonic acid metabolism in esophageal adenocarcinogenesis, and the effects of sulindac, nordihydroguaiaretic acid, and alpha-difluoromethylornithine on tumorigenesis in a rat surgical…
In conclusion, sulindac exerted its chemopreventive effect against the formation of EAC in the rat EGDA model possibly through its inhibition of Cox. Expand
Leukotriene A4 hydrolase in rat and human esophageal adenocarcinomas and inhibitory effects of bestatin.
- Xiaoxin Chen, Ning Li, +6 authors C. Yang
- Journal of the National Cancer Institute
- 16 July 2003
LTA4H overexpression appears to be an early event in esophageal adenocarcinogenesis and is a potential target for the chemoprevention of EAC. Expand
Photochemical reduction of hexavalent chromium in glycerol-containing solutions.
It is suggested that glycerol or related polyols can be used for the remediation of hexavalent (toxic) chromium at contaminated environmental sites. Expand
High WAVE3 expression correlates with proliferation, migration and invasion in human ovarian cancer
It is suggested that WAVE3 may be pivotal in ovarian cancer cell motility, invasion and oncogenesis, which might be related with MMPs production and p38 MAPK pathway. Expand
Docosahexaenoic Acid Modulates Invasion and Metastasis of Human Ovarian Cancer via Multiple Molecular Pathways
- Ying-Chun Wang, Yinan Wu, +4 authors Jinhua Wang
- Biology, Medicine
- International Journal of Gynecologic Cancer
- 1 April 2016
Docosahexaenoic acid inhibited the invasion and metastasis of ovarian cancer cells in vitro and in vivo through the modulation of NF-κB signaling pathway, suggesting that DHA is a promising candidate for ovarian cancer therapy. Expand