Su H Lei

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PURPOSE Fulfilling bioequivalence criteria with highly variable drugs is difficult. The aim of this study was to compare the importance of sample size, intrasubject variability, and the point estimate of test and reference formulations with regard to meeting bioequivalence (BE) criteria [maximum observed plasma concentration (C(max)) and area under the(More)
The detection and reporting of serious adverse drug reactions (SADRs) have become important components of monitoring and evaluation activities performed in hospitals. We present the implementation of a prospective pharmacovigilance program based on automatic laboratory signals (ALSs) at a hospital. We also report the general findings after the first year of(More)
BACKGROUND The first generic PPI was introduced in Spain in 2001, and since then their prescriptions have increased steadily by about 200%. AIM To evaluate the frequency of use and the appropriateness of indications of PPIs in hospitalised patients, and possible factors predicting their use. We also evaluated relevant PPI-drug interactions and serious(More)
DRESS-syndrome (Drug Rash with Eosinophilia and Systemic Symptoms) is a severe drug-induced hypersensitivity syndrome characterized by diffuse maculopapular rash, lymphadenopathy, multivisceral involvement, eosinophilia and atypical lymphocytes with a mortality rate of 10-40% (Seminars in Cutaneous Medicine and Surgery, 1, 250). It is described in adults(More)
BACKGROUND/AIMS To observe the expressing model of galectin-1 in colorectal carcinoma (CRC) progress. METHODOLOGY The expression of galectin-1 in peritumor, adenoma and CRC tissues using immunohistochemistry, western-blotting and RT-PCR was detected. Serum galectin-1 concentrations were detected by ELISA. RESULTS Galectin-1 intensities in peritumor,(More)
Large intestinal obstruction (LIO) in farm animals can cause a ischaemic necrosis of intestinal tissue, eventually leading to death. The roles of endothelin-1 (ET-1) and nitric oxide (NO) are not well understood in the process of LIO, but evidence suggests that endothelial-derived mediators may participate. In the present study, ET-1 concentration and total(More)
BACKGROUND Bipolar radiofrequency (RF) induced tissue fusion is believed to have the potential to seal and anastomose intestinal tissue thereby providing an alternative to current techniques which are associated with technical and functional complications. This study examines the mechanical and cellular effects of RF energy and varying compressive pressures(More)
Modeling is a valuable way to understand a process, and establishing simulation model is an effective way to study land use/cover changes. This paper formed 1990, 2000 and 2010 landscape pattern maps as the bases of modeling with the help of erdas and arcgis, then used Kappa index and overall landscape level's index method to do the model validation, and(More)
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