• Publications
  • Influence
GABAA Receptor-Mediated Tonic Inhibition in Thalamic Neurons
Tonic GABAA receptor-mediated inhibition is typically generated byδ subunit-containing extrasynaptic receptors. Because the δ subunit is highly expressed in the thalamus, we tested whetherExpand
  • 273
  • 45
  • PDF
The slow (<1 Hz) rhythm of non-REM sleep: a dialogue between three cardinal oscillators
The slow (<1 Hz) rhythm, the most important electroencephalogram (EEG) signature of non–rapid eye movement (NREM) sleep, is generally viewed as originating exclusively from neocortical networks. HereExpand
  • 379
  • 34
  • PDF
Are corticothalamic ‘up’ states fragments of wakefulness?
The slow (<1 Hz) oscillation, with its alternating 'up' and 'down' states in individual neurons, is a defining feature of the electroencephalogram (EEG) during slow-wave sleep (SWS). Although thisExpand
  • 294
  • 24
  • PDF
Thalamic Mechanisms of EEG Alpha Rhythms and Their Pathological Implications
During relaxed wakefulness, the human brain exhibits pronounced rhythmic electrical activity in the α frequency band (8-13 Hz). This activity consists of 3 main components: the classic occipital αExpand
  • 383
  • 21
ATP-Dependent Infra-Slow (<0.1 Hz) Oscillations in Thalamic Networks
An increasing number of EEG and resting state fMRI studies in both humans and animals indicate that spontaneous low frequency fluctuations in cerebral activity at <0.1 Hz (infra-slow oscillations,Expand
  • 84
  • 16
  • PDF
Cellular Mechanisms of the Slow (<1 Hz) Oscillation in Thalamocortical Neurons In Vitro
The slow (<1 Hz) rhythm is a defining feature of the electroencephalogram during sleep. Since cortical circuits can generate this rhythm in isolation, it is assumed that the accompanying slowExpand
  • 217
  • 15
Temporal Framing of Thalamic Relay-Mode Firing by Phasic Inhibition during the Alpha Rhythm
Summary Several aspects of perception, particularly those pertaining to vision, are closely linked to the occipital alpha (α) rhythm. However, how the α rhythm relates to the activity of neurons thatExpand
  • 252
  • 12
  • PDF
Infraslow (<0.1 Hz) oscillations in thalamic relay nuclei basic mechanisms and significance to health and disease states.
In the absence of external stimuli, the mammalian brain continues to display a rich variety of spontaneous activity. Such activity is often highly stereotypical, is invariably rhythmic, and can occurExpand
  • 69
  • 11
A Distinct Class of Slow (∼0.2–2 Hz) Intrinsically Bursting Layer 5 Pyramidal Neurons Determines UP/DOWN State Dynamics in the Neocortex
During sleep and anesthesia, neocortical neurons exhibit rhythmic UP/DOWN membrane potential states. Although UP states are maintained by synaptic activity, the mechanisms that underlie theExpand
  • 41
  • 9
  • PDF
Cellular Dynamics of Cholinergically Induced α (8–13 Hz) Rhythms in Sensory Thalamic Nuclei In Vitro
Although EEG α (8–13 Hz) rhythms are traditionally thought to reflect an “idling” brain state, they are also linked to several important aspects of cognition, perception, and memory. Here we showExpand
  • 112
  • 8