Stuart R. Taylor

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1. Single twitch muscle fibres isolated from frogs and toads were microinjected with the Ca2+-sensitive bioluminescent protein aequorin. The fibres contracted normally and emitted flashes of light (aequorin responses) in response to stimulation for many hours thereafter. 2. No luminescence was detected from healthy fibres at rest. 3. The aequorin diffused(More)
Monumenti, Musei e Gallerie Pontificie. This illustrates the state of planetary observation at the beginning of the eighteenth century. Most of the succeeding advances in this field have occurred in the past decade. Preface The technical triumph of manned landings on the Moon and the return of samples from the lunar surface has provided scientists with a(More)
Blocking of potassium channels by internally and externally applied barium ions has been studied in squid giant axons. Internal Ba (3-5 mM) causes rapid decay or "inactivation" of potassium current (IK). The kinetics and degree of block are strongly voltage-dependent. Large positive voltages speed blocking and make it more profound. Raising the external(More)
We have studied the interactions of Ba ion with K channels. Ba2+ blocks these channels when applied either internally or externally in millimolar concentrations. Periodic depolarizations enhance block with internal Ba2+, but diminish the block caused by external Ba2+. At rest, dissociation of Ba2+ from blocked channels is very slow, as ascertained by(More)
The calcium-sensitive bioluminescent protein aequorin has been microinjected into isolated amphibian twitch muscle fibers in order to detect the intracellular calcium transients associated with excitation-contraction coupling. While it is not yet possible to make quantitative estimates of the changes in calcium concentration involved, it is possible to(More)
In quantifying type B potentiation effects, given earlier merely qualitatively, it is found that Zn(2+), 1-50 microM, causes increases in action potential duration, twitch tension, and twitch contraction period time, which are all directly proportional to the log of the concentration. Hence, the duration of the action potential, i.e. the magnitude of its(More)
Calcium-induced calcium release and halothane-induced calcium release from pig sarcoplasmic reticulum (SR) were studied. The SR prepared from pigs susceptible to malignant hyperthermia (MH) was shown to release calcium at a much lower level of calcium content than in normal pig SR. The concentration above which halothane can release calcium is 40 microM for(More)