Stuart R. Leadley

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Due to poly(orthoesters) being susceptible to acid catalysed hydrolysis, these polymers have attracted considerable interest for the controlled delivery of therapeutic agents within biodegradable matrices. The pH-sensitivity of the poly (orthoesters) has lead to several drug delivery systems being developed, whose rate of drug release is predominantly(More)
Introduction. The aim of this work was to elucidate the mechanisms of adhesion of a silicone coating to a corona discharge treated polypropylene (PP) film. A physico-chemical study of the PP surface utilising contact angle measurements, X-ray Photoelectron Spectroscopy (XPS) and Atomic Force Microscopy (AFM) was carried out. These techniques were used to(More)
Time-of-flight secondary ion mass spectrometry (ToF-SIMS) and X-ray photoelectron spectroscopy (XPS) analyses have been used to investigate the dissolution of hydroxyapatite in the presence of titanium chloride suggesting the substitution of titanium ions for calcium in the hydroxyapatite structure. The surface analytical data suggest that titanium was(More)
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