Stuart L Shalat

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IMPORTANCE The causes of late-onset Alzheimer disease (AD) are not yet understood but likely include a combination of genetic, environmental, and lifestyle factors. Limited epidemiological studies suggest that occupational pesticide exposures are associated with AD. Previously, we reported that serum levels of dichlorodiphenyldichloroethylene (DDE), the(More)
Because of their mouthing behaviors, children have a higher potential for exposure to available chemicals through the nondietary ingestion route; thus, frequency of hand-to-mouth activity is an important variable for exposure assessments. Such data are limited and difficult to collect. Few published studies report such information, and the studies that have(More)
BACKGROUND Exposure to pesticides has been reported to increase the risk of Parkinson disease (PD), but identification of the specific pesticides is lacking. Three studies have found elevated levels of organochlorine pesticides in postmortem PD brains. OBJECTIVE To determine whether elevated levels of organochlorine pesticides are present in the serum of(More)
Pesticide exposure has been implicated as an environmental risk factor for the development of Parkinson's disease (PD). However, few studies have identified specific pesticides. Previously, we identified elevated serum levels of the organochlorine pesticide β-hexachlorocyclohexane (β-HCH) in PD patients from a small clinical sample. Here, we conducted a(More)
Attention-deficit hyperactivity disorder (ADHD) is estimated to affect 8-12% of school-age children worldwide. ADHD is a complex disorder with significant genetic contributions. However, no single gene has been linked to a significant percentage of cases, suggesting that environmental factors may contribute to ADHD. Here, we used behavioral, molecular, and(More)
While the association of eczema with asthma is well recognized, little research has focused on the potential role of inhalable exposures and eczema. While indoor air quality is important in the development of respiratory disease as children in the U.S. spend the majority of their time indoors, relatively little research has focused on correlated(More)
An apparent epidemic cluster of toxic liver disease was reexamined among workers exposed to the solvent dimethylformamide. A demographically similar but unexposed group from a preemployment population was used for comparison. Analysis, after data transformation of the liver transaminases, revealed significant differences between the two populations with(More)
  • Cornelia Marja Duijn, Van, Risicofactoren Voor, A Hofman, M F Niermeijer Overige, D G Qayton +42 others
  • 2012
Acknowledgements The work presented in this thesis was made possible by a grant from The Netherlands Organisation for Scientific Research (NWO). The Dutch case-control study of risk factors for Alzheimer's disease was supported by a grant from the SOOM foundation, financed by the Ministry of Health and Welfare. The collaborative re-analysis of case-control
In an evaluation of the usefulness of collecting work exposure information from wives of workers, 26 husband-wife pairs were interviewed separately about exposure of the husband to organic solvents. There was 58% concordance between the husbands and wives for answers to a simple question regarding solvent exposure. Amplification of these answers through the(More)
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