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Institute for Water and Watersheds and Department of Forest Engineering, Resources and Management Oregon State University, Corvallis, OR 97331-5706, USA; School of Geosciences, University of Aberdeen, Aberdeen, Scotland, AB24 3UF UK Virginia Water Resources Research Center & Department of Forestry Virginia Tech, Blacksburg, VA 24061, USA Isotope Hydrology(More)
[1] Field studies in watershed hydrology continue to characterize and catalogue the enormous heterogeneity and complexity of rainfall runoff processes in more and more watersheds, in different hydroclimatic regimes, and at different scales. Nevertheless, the ability to generalize these findings to ungauged regions remains out of reach. In spite of their(More)
The UK and wider international e-Research initiatives are entering a critical phase in which they need to move from the development of the basic underlying technology, demonstrators, prototypes and early applications to wider adoption and the development of stable infrastructures. In this paper we will review existing work on studies of infrastructure and(More)
Nanotechnology can provide a critical advantage in developing strategies for cancer management and treatment by helping to improve the safety and efficacy of novel therapeutic delivery vehicles. This paper reports the fabrication of poly(lactic acid-co-glycolic acid)/siRNA nanoparticles coated with lipids for use as prostate cancer therapeutics made via a(More)
This paper presents the approaches within the Arts and Humanities e-Science Initiative in the UK. It describes some of its early activities, and sketches out how virtual organizations can transform the way in which researchers in these disciplines can collaborate in the use of digital material. The paper is an attempt to position the specific research needs(More)
A project of the AHRC Connected Communities Theme 2 Executive Summary This project sought to establish a credible definition for, and the current state of the art of, crowd-sourcing in the humanities. The questions included what the humanities have learned from other research domains, where crowd-sourcing is being exploited, what the results are, why(More)
Microneedle devices for transdermal drug delivery have recently become an attractive method to overcome the diffusion-limiting epidermis and effectively transport therapeutics to the body. Here, we demonstrate the fabrication of highly reproducible and completely dissolvable polymer microneedles on flexible water-soluble substrates. These biocompatible(More)
A critical need still remains for effective delivery of RNA interference (RNAi) therapeutics to target tissues and cells. Self-assembled lipid- and polymer-based systems have been most extensively explored for transfection with small interfering RNA (siRNA) in liver and cancer therapies. Safety and compatibility of materials implemented in delivery systems(More)
We report on two JISC-funded projects that aimed to enrich the metadata of digitized historical collections with georeferences and other information automatically computed using geoparsing and related information extraction technologies. Understanding location is a critical part of any historical research, and the nature of the collections makes them an(More)