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Microneedle devices for transdermal drug delivery have recently become an attractive method to overcome the diffusion-limiting epidermis and effectively transport therapeutics to the body. Here, we demonstrate the fabrication of highly reproducible and completely dissolvable polymer microneedles on flexible water-soluble substrates. These biocompatible(More)
We report on two JISC-funded projects that aimed to enrich the metadata of digitized historical collections with georeferences and other information automatically computed using geoparsing and related information extraction technologies. Understanding location is a critical part of any historical research, and the nature of the collections makes them an(More)
This paper presents the approaches within the Arts and Humanities e-Science Initiative in the UK. It describes some of its early activities, and sketches out how virtual organizations can transform the way in which researchers in these disciplines can collaborate in the use of digital material. The paper is an attempt to position the specific research needs(More)
The UK and wider international e-Research initiatives are entering a critical phase in which they need to move from the development of the basic underlying technology, demonstrators, prototypes and early applications to wider adoption and the development of stable infrastructures. In this paper we will review existing work on studies of infrastructure and(More)
Nanotechnology can provide a critical advantage in developing strategies for cancer management and treatment by helping to improve the safety and efficacy of novel therapeutic delivery vehicles. This paper reports the fabrication of poly(lactic acid-co-glycolic acid)/siRNA nanoparticles coated with lipids for use as prostate cancer therapeutics made via a(More)
This paper presents preliminary findings from two projects that aim to widen the uptake of e-Infrastructures for research. Through the development of a corpus of evidence and through community engagement, we aim to uncover barriers to adoption, enablers that may facilitate uptake and good practice that may be used by those wishing to engage with(More)
Human movement constitutes a fundamental part of the archaeological process, and of any interpretation of a site's usage; yet there has to date been little or no consideration of how movement observed (in contemporary situations) and inferred (in archaeological reconstruction) can be documented. This paper reports on the Motion in Place Platform project,(More)