Stuart D. Jackson

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A network was established to acquire basic knowledge of Cryptococcus neoformans in IberoAmerican countries. To this effect, 340 clinical, veterinary, and environmental isolates from Argentina, Brazil, Chile, Colombia, Mexico, Peru, Venezuela, Guatemala, and Spain were typed by using M13 polymerase chain reaction-fingerprinting and orotidine monophosphate(More)
We developed a procedure for the preparation of whole transcriptome cDNA libraries depleted of ribosomal RNA from only 1 μg of total RNA. The method relies on a collection of short, computationally selected oligonucleotides, called 'not-so-random' (NSR) primers, to obtain full-length, strand-specific representation of nonribosomal RNA transcripts. In this(More)
Non-coding RNAs (ncRNAs) are an essential class of molecular species that have been difficult to monitor on high throughput platforms due to frequent lack of polyadenylation. Using a polyadenylation-neutral amplification protocol and next-generation sequencing, we explore ncRNA expression in eleven human tissues. ncRNAs 7SL, U2, 7SK, and HBII-52 are(More)
We report what is to our knowledge the first 3-mu;m fiber laser of the 1-W class. 1.7 W of output power and 17.3% slope efficiency (with respect to the launched pump power) at a wavelength of 2.71mum are demonstrated from a double-clad erbium-doped ZBLAN fiber diode pumped at 790 nm. Energy transfer from the Er(3+) lower laser level to a Pr(3+) codopant(More)
Monoubiquitination of histone H2B is a dynamic post-translational histone modification associated with transcriptional elongation and the DNA damage response. To date, dysregulation of histone monoubiquitination has not been linked to pathogenic mutations in genes encoding proteins, or co-factors, catalyzing this modification. The tumor suppressor cell(More)
DNA copy number variations occur within populations and aberrations can cause disease. We sought to develop an improved lab-automatable, cost-efficient, accurate platform to profile DNA copy number. We developed a sequencing-based assay of nuclear, mitochondrial, and telomeric DNA copy number that draws on the unbiased nature of next-generation sequencing(More)
We report on the power scaling to 103 W of a 1.1 microm continuous-wave Yb(3+)-doped silica fiber laser incorporating a point-by-point (PbP) fiber-Bragg grating inscribed directly into the active core using 800 nm femtosecond laser pulses. The spectrum of the laser exhibited a narrow linewidth that broadened to 260 pm at 103 W. The output was frequency(More)
Based on recently published spectroscopic measurements of the relevant energy-transfer parameters, we performed a detailed analysis of the population mechanisms and the characteristics of the output from Er-singly-doped and Er, Pr-codoped ZBLAN fiber lasers operating at 3 m, for various Er concentrations and pump powers. Whereas both approaches resulted in(More)
The operation of a diode-pumped Tm-doped silica fiber laser that uses the cladding-pumping arrangement to produce high-power cw output at wavelengths near 2 microm is reported. We obtained a maximum output power of 5.4 W at a slope efficiency of 31% with respect to the launched pump power at a total optical-to-optical efficiency of 22%. The fiber-laser(More)