Stuart Adams

Austen Worth2
Paul Veys2
Waseem Qasim2
Hubert Gaspar2
2Austen Worth
2Paul Veys
2Waseem Qasim
2Hubert Gaspar
2E. Graham Davies
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S peechActs is a prototype testbed for developing spoken natural language applications. In developing SpeechActs, our primary goal was to enable software developers without special expertise in speech or natural language to create effective conversational speech applications—that is, applications with which users can speak naturally, as if they were(More)
  • Hong Zhan, Kimberly Gilmour, Lucas Chan, Farzin Farzaneh, Anne Marie McNicol, Jin-Hua Xu +6 others
  • 2013
UNLABELLED Suicide gene modified donor T cells can improve immune reconstitution after allogeneic haematopoietic stem cell transplantation (SCT), but can be eliminated in the event of graft versus host disease (GVHD) through the administration of prodrug. Here we report the production and first-in-man use of mismatched donor T cells modified with a(More)
Adenosine deaminase (ADA) deficiency is a systemic disorder of purine metabolism. Deficiency of the purine salvage enzyme ADA leads to the build-up of the toxic metabolites, deoxyadenosine triphosphate and deoxyadenosine. ADA is ubiquitously expressed in all tissues of the body but most profoundly affects lymphocyte development and function leading to(More)
BACKGROUND Severe combined immunodeficiency (SCID) can be cured by using allogeneic hematopoietic stem cell transplantation, and the absence of host immunity often obviates the need for preconditioning. Depending on the underlying genetic defect and when blocks in differentiation occur during lymphocyte ontogeny, infants with SCID have absent or greatly(More)
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