Stuart A Lowther

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Unaccustomed exercise is followed by delayed-onset muscle soreness and morphological changes in skeletal muscle. Animal studies have demonstrated that women have an attenuated response to muscle damage. We studied the effect of eccentric exercise in untrained male (n = 8) and female (n = 8) subjects using a unilateral exercise design [exercise (Ex) and(More)
We studied the effects of a 38-day endurance exercise training program on leucine turnover and substrate metabolism during a 90-min exercise bout at 60% peak O(2) consumption (VO(2 peak)) in 6 males and 6 females. Subjects were studied at both the same absolute (ABS) and relative (REL) exercise intensities posttraining. Training resulted in a significant(More)
Mitochondrial cytopathies are associated with increased free radical generation and paracrystalline inclusions. Paracrystalline inclusions were serendipitously found in a young male athlete with a very high respiratory exchange ratio during steady-state exercise; he also had an unusually low aerobic capacity. Direct sequencing of the mitochondrial DNA(More)
Women use more fat during endurance exercise as evidenced by a lower respiratory exchange ratio (RER). The contribution of intramyocellular lipid (IMCL) to lipid oxidation during endurance exercise is controversial, and studies investigating sex differences in IMCL utilization have found conflicting results. We determined the effect of sex on net IMCL use(More)
We sought to identify factors associated with being a reservoir district for wild poliovirus in Pakistan. Differences between reservoir and non-reservoir districts were identified using acute flaccid paralysis surveillance data, population census statistics and data from a survey of district health officials (DHOs). Of the 11 poliovirus reservoir districts(More)
1World Health Organization, Polio Eradication Initiative, Islamabad, Pakistan (Consultant, 2001). 2World Health Organization, Islamabad, Pakistan. 3National Institutes of Health, Expanded Programme on Immunization, Islamabad, Pakistan, Received: 31/03/03; accepted: 14/01/04 ABSTRACT We sought to identify factors associated with being a reservoir district(More)
McKenzie, Scott, Stuart M. Phillips, Sherry L. Carter, Stuart Lowther, Martin J. Gibala, and Mark A. Tarnopolsky. Endurance exercise training attenuates leucine oxidation and BCOAD activation during exercise in humans. Am J Physiol Endocrinol Metab 278: E580–E587, 2000.—We studied the effects of a 38-day endurance exercise training program on leucine(More)
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