Stoyan G. Lalchev

Learn More
Genetic markers have recently been found to be much more polymorphic than expected. Such extensive human polymorphisms may be partly explained by a number of genetic and environmental factors, including infectious diseases. Malaria, which was very widespread in the past and still poses a problem in many countries today, is a good candidate for research. The(More)
A 2-year-old girl with a probable trisomy-22 translocation is described. The principal clinical symptoms described by the authors who have reported cases with proved trisomy 22 are presented. A probable 46, XX,-21,+t(21q;22q) karyotype was established in the patient. The proband's clinical picture is compared with other trisomy 22 cases described in the(More)
Chloracetophone (O,O-dimethyl-2,2,2-trichloro-1-(chloroacetoxy)phosphonate), a new insecticide of the organophosphorus group of pesticides, was tested for genotoxicity in a variety of systems with different genetic end-points and varying parameters. The test systems included 2 microbial systems, Salmonella and Aspergillus for point mutations and mitotic(More)
The incidence of carriers of the Gd(-) gene and the Rh(+) and Rh(-) alleles was studied in 10 342 Bulgarian individuals living in 306 villages in 5 districts at different altitudes above the sea level. The results showed that the presence of the Gd(-) gene is considerably less frequent in Rh(-) than in Rh(+) individuals. In populations with a high frequency(More)
New generation genomic platforms enable us to decipher the complex genetic basis of complex diseases and Balkan Endemic Nephropathy (BEN) at a high-throughput basis. They give valuable information about predisposing Single Nucleotide Polymorphisms (SNPs), Copy Number Variations (CNVs) or Loss of Heterozygosity (LOH) (using SNP-array) and about(More)
The authors carried out experiment on 38 Syrian hamsters, treated with cyneb, tetracycline and chlorpromasine in groups for a period of tree days. They examined the changes in the cariotypes of the animals as well as the changes in the mytotic activity of bone-marrow cells. Data were based on the analysis of 3045 metaphasic plates and 190,000 cells. It was(More)
The issue of carrier testing for Huntington’s disease (HD) gene is controversial. Careful counselling and follow-up is needed if asymptomatic family members at risk are tested. Though test results are “black or white” in >99% of cases, their interpretation may be quite problematic and difficult in individual cases. Although the identification of the HD gene(More)
  • 1