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Cell adhesion molecules (CAMs) sense the extracellular microenvironment and transmit signals to the intracellular compartment. In this investigation, we addressed the mechanism of signal generation by ectodomains of single-pass transmembrane homophilic CAMs. We analyzed the structure and homophilic interactions of carcinoembryonic antigen (CEA)-related CAM(More)
Skeletonization is a way to reduce dimensionality of digital objects. Here, we present an algorithm that computes the curve skeleton of a surface-like object in a 3D image, i.e., an object that in one of the three dimensions is at most two-voxel thick. A surface-like object consists of surfaces and curves crossing each other. Its curve skeleton is a 1D set(More)
A medial surface representation of a grey-level volume image is computed. The foreground is reduced to a subset topologically equivalent to the initial foreground and mainly consisting of surfaces centred within regions having locally higher intensities, here, regarded as more informative. This result is obtained by combining distance information with(More)
Object decomposition into simpler parts greatly diminishes the complexity of a recognition task. In this paper, we present a method to decompose a 3D discrete object into nearly convex or elongated parts. Object decomposition is guided by the distance transform (DT). Significant voxels in DT are identified and grouped into seeds. These are used to originate(More)
In many applications thinning of objects is of great interest. We here present a skeletonization algorithm that is based on the idea of iteratively thinning the distance transform of an object layer by layer until either an anchor-point is reached or the connectivity breaks. Our algorithm is general in the sense that any metric and any connectivity can be(More)