Stig Kraglund Holfort

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To study long-term changes in retinal function in response to sustained glycaemia reduction in participants with type 1 diabetes. Prospective study using objective measures of retinal function in 17 participants with type 1 diabetes mellitus and minimal to moderate retinopathy who switched from conventional subcutaneous injection to continuous subcutaneous(More)
It was the purpose of the present study to examine dark adaptation in subjects with type 2 diabetes during transient hyperglycemia. Twenty-four subjects with type 2 diabetes and minimal diabetic retinopathy were randomized to undergo an oral glucose tolerance test (OGTT) or to remain fasting. Dark adaptometry was measured in one eye, chosen at random, using(More)
PURPOSE To examine dark-adapted retinal function in subjects with type 2 diabetes during transient hyperglycemia. METHODS Twenty-four subjects with type 2 diabetes and minimal diabetic retinopathy were randomized to an oral glucose tolerance test (OGTT) or a fasting regimen. One study eye was kept in the dark-adapted state at all times. Full-field(More)
PURPOSE To analyze retinal structure and function in vitelliform macular dystrophy (VMD) due to mutations in BEST1. METHODS Patients from five Swedish and four Danish families were examined with electrooculography (EOG), full-field electroretinography (ffERG), multifocal ERG (mfERG), optical coherence tomography (OCT), and fundus autofluorescence(More)
IMPORTANCE Inflammation may contribute to the pathogenesis of diabetic retinopathy (DR). OBJECTIVES To investigate, in a proof-of-concept clinical trial, whether low-dose oral doxycycline monohydrate can (1) slow the deterioration of, or improve, retinal function or (2) induce regression or slow the progression of DR in patients with severe(More)
Purpose. To examine retinal function in chronic ocular ischemia using multifocal electroretinography (mfERG). Methods. Thirteen patients with unilateral ocular ischemic syndrome (OIS) underwent assessment of ophthalmic systolic blood pressure by ocular pneumoplethysmography, carotid artery patency by ultrasonography, intraocular pressure (IOP) by(More)
AIM To characterise uveal melanoma that has metastasised to the central nervous system (CNS). METHODS Review of 2365 patients constituting all patients diagnosed as having primary uveal melanoma in Denmark during the period 1943-1997. All patients with malignant uveal melanoma and metastasis to the CNS were identified. For each patient, clinical and(More)
PURPOSE To examine retinal function in relation to retinal perfusion pressure in patients with carotid artery stenosis. METHODS Thirteen patients with carotid artery stenosis without clinical eye disease underwent assessment of ophthalmic artery systolic blood pressure (OSP) by ocular pneumoplethysmography, carotid artery obstructive disease by(More)
The purpose of the study was to characterize the long-term effect of insulin pump therapy (CSII) on electroretinography and dark adaptometry and to examine the influence of baseline glycaemic control on retinal function in patients with type 1 diabetes mellitus. This prospective observational extension study enrolled 13 patients out of 17 who completed a(More)