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Web applications rely on servers to store and process confidential information. However, anyone who gains access to the server (e.g., an attacker, a curious administrator, or a government) can obtain all of the data stored there. This paper presents Mylar, a platform that provides end-to-end encryption to web applications. Mylar protects the confidentiality(More)
Insulin and insulin-like growth factor 1 (IGF-1) receptor signaling pathways differentially modulate cardiac growth under resting conditions and following exercise training. These effects are mediated by insulin receptor substrate 1 (IRS1) and IRS2, which also differentially regulate resting cardiac mass. To determine the role of IRS isoforms in mediating(More)
The induction of autophagy in the mammalian heart during the perinatal period is an essential adaptation required to survive early neonatal starvation; however, the mechanisms that mediate autophagy suppression once feeding is established are not known. Insulin signaling in the heart is transduced via insulin and IGF-1 receptors (IGF-1Rs). We disrupted(More)
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