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UNLABELLED Lectin-like Oxidized Low-Density Lipoprotein Receptor 1 (LOX-1) plays a key role in atherosclerotic plaque initiation, formation and rupture, as well as in hyperlipidemia-induced glomerular disease. Here we report a sensitive, specific and biocompatible LOX-1-targeted-USPIO for the noninvasive MR imaging of LOX-1 within carotid atherosclerotic(More)
The mass transport characteristics of cationic, nonviral liposome-DNA plasmid complexes (lipoplexes) were evaluated over a range of fluid shear stresses. The typical case of stagnant flow transfection was expanded to include controlled fluid convection provided by constant flow through a parallel plate flow chamber. Equations describing the transport of(More)
Magnetic resonance imaging (MRI) allows for noninvasive, deep tissue imaging with high spatial resolution, making it an attractive modality for in vivo cellular imaging. Since reporter genes can generate magnetic resonance (MR) contrast based on molecular activity, they offer a potentially powerful tool for cellular imaging. The mms6 gene was originally(More)
Phycomyces sporangiophores showl a growth response to a light stimus and an avoidance bending response to a physical barrier. A bluie-light stimnlluts Imninisteredl in conjunction with a barrier interferes with the avoidance bending sponse. This interference begins ifter a latency of abotit 3 minultes atndt continues a period of 4 to 5 minutes.
Superparamagnetic iron oxide nanoparticles produce changes in the surrounding microscopic magnetic field. A method for generating contrast based on the application of an adiabatic preparation pulse and the failure of the adiabatic condition surrounding the nanoparticles is introduced in this article. Images were obtained in the presence and absence of an(More)
iv ACKNOWLEDGEMENTS I would like thank my advisor, Dr. Xiaoping Hu, for his guidance and support. His encouragement of my broad research interests has enriched my graduate school experience. I am also grateful to my committee, Dr. and Dr. Xiaodong Zhang for their guidance and advice. v I would also like to thank Dr. Jue Zhang of Peking University for their(More)
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