Steven R. Skinner

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  • James E Steck, Steven R Skinner, Alvaro A Cruz-Cabrera, Mingtao Yang, Elizabeth C Behrman
  • 2007
Artificial neural networks are learning systems modeled loosely after the architecture of the brain. These are usually envisioned as a collection of discrete nonlinear processors called artificial neurons with a massive number of artificial synapses connecting them together. A major hurdle, when attempting to build neural networks in hardware is(More)
The optical bench training of an optical feedforward neural network, developed by the authors, is presented. The network uses an optical nonlinear material for neuron processing and a trainable applied optical pattern as the network weights. The nonlinear material, with the applied weight pattern, modulates the phase front of a forward propagating(More)
Fumagillin, an irreversible inhibitor of MetAP2, has been shown to potently inhibit growth of malaria parasites in vitro. Here, we demonstrate activity of fumagillin analogs with an improved pharmacokinetic profile against malaria parasites, trypanosomes, and amoebas. A subset of the compounds showed efficacy in a murine malaria model. The observed SAR(More)
The optical bench realization of a feed forward optical neural network, developed by the authors, is presented. The network uses a thermal nonlinear material that modulates the phase front of a forward propagating HeNe beam by dynamically altering the index of refraction profile of the material. The index of refraction cross-section of the nonlinear(More)