Steven P. Sourbron

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Dynamic contrast-enhanced MRI (DCE-MRI) is a functional MRI method where T1 -weighted MR images are acquired dynamically after bolus injection of a contrast agent. The data can be interpreted in terms of physiological tissue characteristics by applying the principles of tracer-kinetic modelling. In the brain, DCE-MRI enables measurement of cerebral blood(More)
The Tofts model (TM) and extended Tofts model (ETM) have become a standard for the analysis of dynamic contrast-enhanced MRI. In this study, a mathematical analysis is used to identify exactly in which tissue types the Tofts models may be applied. The results show that the TM is accurate if and only if the tissue is weakly vascularised (small blood volume).(More)
Dynamic susceptibility contrast MRI (DSC-MRI) is the current standard for the measurement of Cerebral Blood Flow (CBF) and Cerebral Blood Volume (CBV), but it is not suitable for the measurement of Extraction Flow (EF) and may not allow for absolute quantification. The objective of this study was to develop and evaluate a methodology to measure CBF, CBV,(More)
The tracer-kinetic models developed in the early 1990s for dynamic contrast-enhanced MRI (DCE-MRI) have since become a standard in numerous applications. At the same time, the development of MRI hardware has led to increases in image quality and temporal resolution that reveal the limitations of the early models. This in turn has stimulated an interest in(More)
The most common methods for measuring perfusion with MRI are arterial spin labelling (ASL), dynamic susceptibility contrast (DSC-MRI), and T(1)-weighted dynamic contrast enhancement (DCE-MRI). This review focuses on the latter approach, which is by far the most common in the body and produces measures of capillary permeability as well. The aim is to present(More)
OBJECTIVES Recent animal studies with dynamic contrast enhanced magnetic resonance imaging have demonstrated that a separable compartment model provides more accurate assessments of glomerular filtration than the Patlak model. In this study, the feasibility of the separable compartment model for the measurement of perfusion and filtration in healthy humans(More)
PURPOSE The aim of this study was to investigate if a quantitative evaluation of a magnetic resonance (MR) perfusion examination of the myocardium can achieve a comparable diagnostic accuracy as a semiquantitative evaluation. METHODS A total of 31 patients with suspected coronary artery disease underwent MR imaging and conventional coronary angiography.(More)
Diffusion and perfusion MR imaging are now being used increasingly in neuro-vascular clinical applications. While diffusion weighted magnetic resonance imaging exploits the translational mobility of water molecules to obtain information on the microscopic behaviour of the tissues (presence of macromolecules, presence and permeability of membranes,(More)
OBJECTIVE To assess the required temporal resolution and total acquisition time for renal perfusion and filtration measurements with a 2-compartment model. MATERIAL AND METHODS Saturation-recovery TurboFLASH perfusion measurements of 15 healthy volunteers were acquired at 1.5 T, with a temporal resolution of 1 second during the first pass and a total(More)
PURPOSE To investigate the influence of the contrast-to-noise ratio (CNR) and temporal resolution of 3D dynamic contrast-enhanced magnetic resonance imaging on the quantification of pulmonary perfusion parameters by means of Monte-Carlo simulations and a volunteer study. METHODS Quantification of perfusion parameters such as pulmonary blood flow (PBF) and(More)