Steven Ostrove

Learn More
A new, potent hypocholesterolemic agent is produced by cultures of Aspergillus terreus. The isolation of the compound and its characterization as 4a,5-dihydromevinolin containing a trans-fused octahydro-naphthalene system are described. Comparative data for dihydromevinolin and mevinolin in three biological assays are given: in vitro inhibition of HMG-CoA(More)
A tritium labeled 5 alpha-reductase inhibitor, [1,2-3H] 17 beta-N,N-diethylcarbamoyl-4-methyl-4-aza-5 alpha-androstan-3-one ([3H]4-MA), binds reversibly to a high affinity site (Kd, 6.5 nM) in liver microsomes from male rats. The binding requires a nicotinamide nucleotide coenzyme; NADH is at least 100 times less potent than NADPH, and NADP+, NAD+, flavin(More)
A line of mouse cells expressing hepatitis B virus (HBV) surface and 'e' antigens identical in their physico-chemical properties to antigens from patients infected with HBV was isolated after transfection of 3T3 cells with cloned HBV DNA. The studies reported here indicate that the cells contain uninterrupted copies of the entire HBV genome which are(More)
  • 1