Steven M Sigelman

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BACKGROUND Children with asthma in low-income urban areas have high morbidity. Phenotypic analysis in these children is lacking, but may identify characteristics to inform successful tailored management approaches. OBJECTIVE We sought to identify distinct asthma phenotypes among inner-city children receiving guidelines-based management. METHODS Nine(More)
BACKGROUND Pathway analyses can be used to determine how host and environmental factors contribute to asthma severity. OBJECTIVE To investigate pathways explaining asthma severity in inner-city children. METHODS On the basis of medical evidence in the published literature, we developed a conceptual model to describe how 8 risk-factor domains (allergen(More)
BACKGROUND Treatment levels required to control asthma vary greatly across a population with asthma. The factors that contribute to variability in treatment requirements of inner-city children have not been fully elucidated. OBJECTIVE We sought to identify the clinical characteristics that distinguish difficult-to-control asthma from easy-to-control(More)
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