UNLABELLED CT and PET are widely used to characterize solitary pulmonary nodules (SPNs). However, most CT accuracy studies have been performed with outdated technology and methods, and previous PET studies have been limited by small sample sizes and incomplete masking. Our objective was to compare CT and PET accuracy in veterans with SPN. METHODS Between… (More)
PURPOSE The Ocular Hypertension Treatment Study (OHTS) demonstrated that medical treatment of people with intraocular pressure (IOP) of > or =24 mm Hg reduces the risk of the development of primary open-angle glaucoma (POAG) by 60%. There is no consensus on which people with ocular hypertension would benefit from treatment. DESIGN Cost-utility analysis… (More)
BACKGROUND The purpose of this paper was to demonstrate the use of an online service for conducting a systematic review and meta-analysis of the efficacy of topical prostaglandin analogs in reducing intraocular pressure (IOP) in glaucoma and ocular hypertension. METHODS An online service provider (Doctor Evidence) reviewed and extracted data from the… (More)
the cost–benefit of nerve conduction studies in pre-employment screening for carpal tunnel syndrome".
OBJECTIVES Automatic prescription refill programs are a popular means of improving medication adherence. A concern is the potential for prescription drug wastage and unnecessary healthcare spending. We evaluated the impact of an automatic refill program on patterns of medication use. STUDY DESIGN Retrospective propensity score matched cohort study with… (More)
Accommodative amplitude (AA; the difference, measured in diopters, between the near and far points of vision) declines steadily with age such that, by midlife, most individuals are unable to focus clearly on near objects and, thus, are said to be presbyopic. Conversely, intrinsic lens fluorescence (LF) increases steadily with age. Previous studies have… (More)
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Heart disease is the leading cause of death among Americans and of premature disability in the US labor force, accounting for 19% of the disability allowance paid annually by the Social Security Administration. It is estimated that each year more than 1 million persons have a new or recurrent myocardial infarction, with a 1-year mortality rate approaching… (More)