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  • D H Nguyen, Andrew D. Catling, +5 authors Steven L Gonias
  • Medicine, Biology
  • The Journal of cell biology
  • 1999 (First Publication: 12 July 1999)
  • Urokinase-type plasminogen activator (uPA) activates the mitogen activated protein (MAP) kinases, extracellular signal-regulated kinase (ERK) 1 and 2, in diverse cell types. In this study, weContinue Reading
  • Konstantin Stoletov, Valérie Montel, Robin D. Lester, Steven L Gonias, Richard L. Klemke
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 2007 (First Publication: 30 October 2007)
  • Cell metastasis is a highly dynamic process that occurs in multiple steps. Understanding this process has been limited by the inability to visualize tumor cell behavior in real time by using animalContinue Reading
  • Elisabetta Mantuano, Gen Inoue, +4 authors Wendy M Campana
  • Biology, Medicine
  • The Journal of neuroscience : the official…
  • 2008 (First Publication: 5 November 2008)
  • Low-density lipoprotein receptor-related protein (LRP-1) is an endocytic receptor for diverse proteins, including matrix metalloproteinase-9 (MMP-9), and a cell-signaling receptor. In the peripheralContinue Reading
  • Minji Jo, Robin D. Lester, Valérie Montel, Boryana M. Eastman, Shinako Takimoto, Steven L Gonias
  • Biology, Medicine
  • The Journal of biological chemistry
  • 2009 (First Publication: 21 August 2009)
  • Hypoxia induces expression of the urokinase receptor (uPAR) and activates uPAR-dependent cell signaling in cancer cells. This process promotes epithelial-mesenchymal transition (EMT). uPARContinue Reading
  • D H Nguyen, Isa Marte Hussaini, Steven L Gonias
  • Biology, Medicine
  • The Journal of biological chemistry
  • 1998 (First Publication: 3 April 1998)
  • Binding of urokinase-type plasminogen activator (uPA) to its receptor, uPAR, regulates cellular adhesion, migration, and tumor cell invasion. Some of these activities may reflect the ability of uPARContinue Reading
  • Jonathan Lamarre, Gordon K. Wollenberg, Steven L Gonias, Michael Anthony Hayes
  • Biology, Medicine
  • Laboratory investigation; a journal of technical…
  • 1991 (First Publication: 1 July 1991)
  • Multiple mechanisms are necessary to spatially and temporally restrict and direct the effects of potent mediators of inflammation, immune reactions and tissue repair. Recent studies implicate alphaContinue Reading
  • Kebin Hu, Junwei Yang, Sakae Tanaka, Steven L Gonias, Wendy M Mars, Youhua Liu
  • Biology, Medicine
  • The Journal of biological chemistry
  • 2006 (First Publication: 27 January 2006)
  • Tissue-type plasminogen activator (tPA), a serine protease well known for generating plasmin, has been demonstrated to induce matrix metalloproteinase-9 (MMP-9) gene expression and protein secretionContinue Reading
  • Minji Jo, Keena S. Thomas, Denise O'Donnell, Steven L Gonias
  • Biology, Medicine
  • The Journal of biological chemistry
  • 2003 (First Publication: 17 January 2003)
  • Urokinase-type plasminogen activator (uPA) and vitronectin activate cell-signaling pathways by binding to the uPA receptor (uPAR). Because uPAR is glycosylphosphatidylinositol-anchored, the signalingContinue Reading