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  • Phillip W. Hargrove, Steven Kepes, +6 authors Derek A. Persons
  • Biology, Medicine
  • Molecular therapy : the journal of the American…
  • 2008 (First Publication: 1 March 2008)
  • Although hematopoietic cell gene therapy using retroviral vectors has recently achieved success in clinical trials, safety issues regarding vector insertional mutagenesis have emerged. VectorExpand
    Since increased fetal hemoglobin diminishes the severity of β-thalassemia and sickle cell anemia, a strategy using autologous, stem cell–targeted gene transfer of a γ-globin gene may beExpand
    Since increased fetal hemoglobin diminishes the severity of beta-thalassemia and sickle cell anemia, a strategy using autologous, stem cell-targeted gene transfer of a gamma-globin gene may beExpand
  • Yoon-Sang Kim, Matthew M. Wielgosz, +4 authors A. W. Nienhuis
  • Biology, Medicine
  • Molecular therapy : the journal of the American…
  • 2010 (First Publication: 1 July 2010)
  • Lentiviral vectors are useful for transducing primitive hematopoietic cells. We examined four envelope proteins for their ability to mediate lentiviral transduction of mobilized human CD34(+)Expand
  • Phillip W. Hargrove, Steven Kepes, +4 authors Derek A. Persons
  • Biology
  • 2004 (First Publication: 16 November 2004)
  • The development of lymphoid leukemia in two children with X-SCID who underwent gene therapy was partially due to activation of the LMO-2 proto-oncogene by the retroviral LTR of the vector whichExpand