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BACKGROUND We tested the hypothesis that prophylactic cardiac-resynchronization therapy in the form of biventricular stimulation with a pacemaker with or without a defibrillator would reduce the risk of death and hospitalization among patients with advanced chronic heart failure and intraventricular conduction delays. METHODS A total of 1520 patients who(More)
BACKGROUND Results of previous studies support the hypothesis that implantable haemodynamic monitoring systems might reduce rates of hospitalisation in patients with heart failure. We undertook a single-blind trial to assess this approach. METHODS Patients with New York Heart Association (NYHA) class III heart failure, irrespective of the left ventricular(More)
BACKGROUND The factors that determine the risk for sudden death or implantable cardioverter defibrillator therapy in patients receiving cardiac resynchronization therapy (CRT) therapies are largely unknown. METHODS AND RESULTS We hypothesized that clinical measures of heart failure severity and the presence of comorbid conditions would predict the risk of(More)
SUMMARY This paper reports an intercomparison study of midlatitude continental cumulus convection simulated by eight two-dimensional and two three-dimensional cloud-resolving models (CRMs), driven by observed large-scale advective temperature and moisture tendencies, surface turbulent fluxes, and radiativl~-heating profiles during three sub-periods of the(More)
SUMMARY This study reports the Single-Column Model (SCM) part of the Atmospheric Radiation Measurement (ARM)/the Global Energy and Water Cycle Experiment (GEWEX) Cloud System Study (GCSS) joint SCM and Cloud-Resolving Model (CRM) Case 3 intercomparison study, with a focus on evaluation of cumulus parametrizations used in SCMs. Fifteen SCMs are evaluated(More)
Cloud amount statistics from three different sources were processed and compared. Surface observations from a National Centers for Environmental Prediction dataset were used. The data (Edited Cloud Report; ECR) consist of synoptic weather reports that have been edited to facilitate cloud analysis. Two stations near the Southern Great Plains (SGP) Cloud and(More)
BACKGROUND Left ventricular assist devices (LVADs) have improved survival in patients with end-stage heart failure. Compared with previous trials, the Randomized Evaluation of Mechanical Assistance in Treatment of Chronic Heart Failure (REMATCH) trial enrolled patients with more advanced heart failure and high prevalence of intravenous inotropic therapy.(More)
The polymorphic variants at codon 72 of the p53 gene were shown to be functionally distinct in vitro, whereby the arginine (arg) variant induces apoptosis more efficiently than the proline (pro) variant. From the evidence that the DNA mismatch repair system and p53 interact to maintain genomic integrity, we hypothesized that the codon 72 variation may(More)