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  • Kenneth G. Hadlock, Robert E. Lanford, +6 authors Steven K H Foung
  • Biology, Medicine
  • Journal of virology
  • 2000 (First Published: 15 November 2000)
  • The intrinsic variability of hepatitis C virus (HCV) envelope proteins E1 and E2 complicates the identification of protective antibodies. In an attempt to identify antibodies to E2 proteins fromContinue Reading
  • Dorothea Bankwitz, Eike Steinmann, +9 authors Thomas Pietschmann
  • Biology, Medicine
  • Journal of virology
  • 2010 (First Published: 1 June 2010)
  • The variability of the hepatitis C virus (HCV), which likely contributes to immune escape, is most pronounced in hypervariable region 1 (HVR1) of viral envelope protein 2. This domain is the targetContinue Reading
  • Zhen-yong Keck, Jinming Xia, +10 authors Steven K H Foung
  • Biology, Medicine
  • PLoS pathogens
  • 2012 (First Published: 12 April 2012)
  • The majority of broadly neutralizing antibodies to hepatitis C virus (HCV) are against conformational epitopes on the E2 glycoprotein. Many of them recognize overlapping epitopes in a cluster,Continue Reading
  • C. H. Chan, Kenneth G. Hadlock, Steven K H Foung, Shoshana Levy
  • Biology, Medicine
  • Blood
  • 2001 (First Published: 15 February 2001)
  • Hepatitis C virus (HCV)-associated B cell lymphomas were previously shown to express a restricted repertoire of immunoglobulin V(H) and V(L) genes, V(H)1-69 and VkappaA27, respectively. Although thisContinue Reading
  • Zhen-yong Keck, Sophia H Li, +8 authors Steven K H Foung
  • Medicine, Biology
  • Journal of virology
  • 2009 (First Published: 15 June 2009)
  • Broadly neutralizing antibodies are commonly present in the sera of patients with chronic hepatitis C virus (HCV) infection. To elucidate possible mechanisms of virus escape from these antibodies,Continue Reading
  • Elizabeth R. Quinn, C. H. Chan, Kenneth G. Hadlock, Steven K H Foung, Mikhail Flint, Shoshana Levy
  • Medicine, Biology
  • Blood
  • 2001 (First Published: 15 December 2001)
  • Hepatitis C virus (HCV) infection is associated with extrahepatic B-cell lymphoproliferative disorders. To determine whether a viral antigen drives this B-cell expansion, the B-cell receptors wereContinue Reading
  • Jane A. Potter, Ania M. Owsianka, +6 authors Arvind H Patel
  • Biology, Medicine
  • Journal of virology
  • 2012 (First Published: 1 December 2012)
  • The E2 envelope glycoprotein of hepatitis C virus (HCV) binds to the host entry factor CD81 and is the principal target for neutralizing antibodies (NAbs). Most NAbs recognize hypervariable region 1Continue Reading
  • Ann M. Arvin, Celine M. Koropchak, B. R. Williams, F. Carl Grumet, Steven K H Foung
  • Medicine
  • The Journal of infectious diseases
  • 1986 (First Published: 1 September 1986)
  • Events in pathogenesis and immunity during primary varicella-zoster virus (VZV) infection were examined in 64 healthy subjects and 21 immunocompromised patients. Activation of the interferon systemContinue Reading