Steven K. Boyd

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  • Helen R Buie, Graeme M Campbell, R Joshua Klinck, Joshua A MacNeil, Steven K Boyd
  • 2007
The use of high resolution peripheral quantitative computed tomography (HR-pQCT) and in vivo micro-CT for studies of bone disease and treatment has become increasingly common, and with these methods comes large quantities of data requiring analysis. A simple, robust, and fully-automated segmentation algorithm is presented that efficiently segments bone(More)
A new approach for the study of geometric morphometrics is presented based on well-established image processing techniques in a novel combination to support high-throughput analysis necessary for large-scale determination of genotype-phenotype relationships. The method retains full 3-D data, and avoids manual landmark selection. Micro-computed tomography(More)
  • Alla Bondareva, Charlene M. Downey, Fabio Ayres, Wei Liu, Steven K. Boyd, Benedikt Hallgrimsson +1 other
  • 2009
Lysyl oxidase (LOX), an extracellular matrix remodeling enzyme, appears to have a role in promoting breast cancer cell motility and invasiveness. In addition, increased LOX expression has been correlated with decreases in both metastases-free, and overall survival in breast cancer patients. With this background, we studied the ability of(More)
Cleft lip and palate (CL/P), as is true of many craniofacial malformations in humans, is etiologically complex and highly variable in expression. A/WySn mice are an intriguing model for human CL/P because they develop this dysmorphology with a variable expression pattern, incomplete penetrance and frequent unilateral expression on a homogeneous genetic(More)
Quantitative cortical microarchitectural end points are important for understanding structure-function relations in the context of fracture risk and therapeutic efficacy. This technique study details new image-processing methods to automatically segment and directly quantify cortical density, geometry, and microarchitecture from HR-pQCT images of the distal(More)
High-frequency, low-magnitude vibration enhances bone formation ostensibly by mimicking normal postural muscle activity. We tested this hypothesis by examining whether daily exposure to low-magnitude vibration (VIB) would maintain bone in a muscle disuse model with botulinum toxin type A (BTX). Female 16-18 wk old BALB/c mice (N = 36) were assigned to(More)
INTRODUCTION As the gateway of nutrient supply, the vertebral endplate is essential to maintain the integrity and function of the avascular intervertebral disk. While a link between calcium deposition in the endplate and disk degeneration is well established from histological studies, findings on the association between endplate thickness and age and disk(More)
Subject motion during acquisition of high-resolution peripheral quantitative computed tomography (HR-pQCT) results in image artifacts and interferes with quantification of bone architecture used to study bone-related diseases such as osteoporosis. We propose an automatic method to measure physical subject motion that frequently takes place during(More)
In vivo micro-computed tomography (microCT) is a new method to monitor longitudinal changes of bone micro-architecture. Common animal models of bone diseases are mice and rats, and it is important to know the reproducibility of the bone measurements in order to correctly interpret results. When performing baseline and follow-up acquisitions, variation in(More)
The advent of in vivo micro-computed tomography (micro-CT) provides a novel approach to measure the temporal adaptation of bone micro-architecture within an individual. Spatial alignment in the scanner between serial scans is challenging, but three-dimensional image registration can be used to superimpose the resulting image data, thus ensuring consistent(More)