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PYK2 regulates SERCA2 gene expression in neonatal rat ventricular myocytes.

• Maria C. Heidkamp, Brian T. Scully, K. K. Vidya Vijayan, Steven J Engman, Erika L. Szotek, Allen M. Samarel
• American journal of physiology. Cell physiology
• 2005

The nonreceptor protein tyrosine kinase (PTK) proline-rich tyrosine kinase 2 (PYK2) has been implicated in cell signaling pathways involved in left ventricular hypertrophy and heart failure, but its… (More)

Focal adhesion kinase-related nonkinase inhibits vascular smooth muscle cell invasion by focal adhesion targeting, tyrosine 168 phosphorylation, and competition for p130(Cas) binding.

• Yevgeniya E. Koshman, Miensheng Chu, +4 authors Allen M. Samarel
• Arteriosclerosis, thrombosis, and vascular…
• 2011

OBJECTIVE Focal adhesion kinase-related nonkinase (FRNK), the C-terminal domain of focal adhesion kinase (FAK), is a tyrosine-phosphorylated, vascular smooth muscle cell (VSMC)-specific inhibitor of… (More)

Expression of Vascular Endothelial Growth Factor Receptors in Benign Vascular Lesions of the Orbit: A Case Series.

• Elizabeth A Atchison, James A. Garrity, Francisco Castillo, Steven J Engman, Steven M. Couch, Diva R. Salomão
• Ophthalmology
• 2016

PURPOSE Vascular lesions of the orbit, although not malignant, can cause morbidity because of their location near critical structures in the orbit. For the same reason, they can be challenging to… (More)

FRNK inhibition of focal adhesion kinase-dependent signaling and migration in vascular smooth muscle cells.

• Yevgeniya E. Koshman, Taehoon Kim, +4 authors Allen M. Samarel
• Arteriosclerosis, thrombosis, and vascular…
• 2010

OBJECTIVE To examine whether interference with FRNK targeting to focal adhesions (FAs) affects its inhibitory activity and tyrosine phosphorylation. METHODS AND RESULTS Focal adhesion kinase and… (More)

Role of FRNK tyrosine phosphorylation in vascular smooth muscle spreading and migration.

• Yevgeniya E. Koshman, Steven J Engman, Taehoon Kim, Rekha Iyengar, Kyle K. Henderson, Allen M. Samarel
• Cardiovascular research
• 2010

AIMS Focal adhesion kinase (FAK) and its autonomously expressed, C-terminal inhibitor FAK-related non-kinase (FRNK), are important regulators of vascular smooth muscle cell (VSMC) spreading and… (More)

PYK2 expression and phosphorylation increases in pressure overload-induced left ventricular hypertrophy.

• Allison L Bayer, Maria C. Heidkamp, Nehu C Patel, Michael J Porter, Steven J Engman, Allen M. Samarel
• American journal of physiology. Heart and…
• 2002

Proline-rich tyrosine kinase 2 (PYK2) is a member of the focal adhesion kinase (FAK) family of nonreceptor protein tyrosine kinases. PYK2 has been implicated in linking G protein-coupled receptors to… (More)

Administration of repeat intravitreal anti-VEGF drugs by retina specialists in an injection-only clinic for patients with exudative AMD: patient acceptance and safety.

• Steven J Engman, Albert O. Edwards, Sophie J. Bakri
• Seminars in ophthalmology
• 2011

PURPOSE To report patient acceptance and safety of repeated intravitreal injections of anti-VEGF agents for exudative AMD, by retina specialists, without an eye examination before every injection. … (More)

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