Steven J Alexander

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BACKGROUND Endothelial MAdCAM-1 (mucosal addressin cell adhesion molecule-1) expression is associated with the oxidant-dependent induction and progress of inflammatory bowel disease (IBD). Melatonin, a relatively safe, potent antioxidant, has shown efficacy in several chronic injury models may limit MAdCAM-1 expression and therefore have a therapeutic use(More)
Multiple sclerosis (MS) is perceived to be an immunemediated disease of the human central nervous system, characterized by a relapsing and progressive clinical course, which eventually leads to irreversible disability in many patients. The cause of and cure for MS remain elusive at this time. While the pathogenesis of MS includes a number of well-recognized(More)
Sasaki, Makoto, John W. Elrod, Paul Jordan, Makoto Itoh, Takashi Joh, Alireza Minagar, and J. Steven Alexander. CYP450 dietary inhibitors attenuate TNF-stimulated endothelial molecule expression and leukocyte adhesion. Am J Physiol Cell Physiol 286: C931–C939, 2004; 10.1152/ajpcell.00351.2003.—Enhanced expression of mucosal addressin cell adhesion(More)
Langley, Robert R., Janice Russell, Michael J. Eppihimer, Steven J. Alexander, Mary Gerritsen, Robert D. Specian, and D. Neil Granger. Quantification of murine endothelial cell adhesion molecules in solid tumors. Am. J. Physiol. 277 (Heart Circ. Physiol. 46): H1156–H1166, 1999.— Coordinated adhesive interactions between lymphocyte receptors and endothelial(More)
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