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BACKGROUND AND METHODS Use of nicotine-replacement therapies and the antidepressant bupropion helps people stop smoking. We conducted a double-blind, placebo-controlled comparison of sustained-release bupropion (244 subjects), a nicotine patch (244 subjects), bupropion and a nicotine patch (245 subjects), and placebo (160 subjects) for smoking cessation.(More)
BACKGROUND There is notable heterogeneity in the clinical presentation of patients with COPD. To characterise this heterogeneity, we sought to identify subgroups of smokers by applying cluster analysis to data from the COPDGene study. METHODS We applied a clustering method, k-means, to data from 10 192 smokers in the COPDGene study. After splitting the(More)
In immunocompetent patients with community acquired pneumonia, as well as in the immunocompe-tent host with nosocomial pneumonia, a calculated therapy can be initiated without prior invasive diagnostic procedure. This kind of patient management, however, is not warranted in immunocompromised or immunodeficient patients, in whom an exact diagnosis and the(More)
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