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Lack of reproducibility of findings has been a criticism of genetic association studies on complex diseases, such as chronic obstructive pulmonary disease (COPD). We selected 257 polymorphisms of 16 genes with reported or potential relationships to COPD and genotyped these variants in a case-control study that included 953 COPD cases and 956 control(More)
Sleep quality is often poor in patients with chronic obstructive pulmonary disease (COPD), but these night-time symptoms are frequently unnoticed by physicians and/or not reported by patients themselves. Therefore, the prevalence and clinical impact of sleep disturbances and night-time symptoms in COPD is not well understood and has not been a clinical(More)
The objective of Integrated Care Pathways for Airway Diseases (AIRWAYS-ICPs) is to launch a collaboration to develop multi-sectoral care pathways for chronic respiratory diseases in European countries and regions. AIRWAYS-ICPs has strategic relevance to the European Union Health Strategy and will add value to existing public health knowledge by: 1)(More)
BACKGROUND There is notable heterogeneity in the clinical presentation of patients with COPD. To characterise this heterogeneity, we sought to identify subgroups of smokers by applying cluster analysis to data from the COPDGene study. METHODS We applied a clustering method, k-means, to data from 10 192 smokers in the COPDGene study. After splitting the(More)
12 A ship sinks at sea. The occupants are left floating in the ocean aided only by their life preservers and buoyant pieces of debris. Fortunately, a CoastGuard cutter, attracted by an SOS sent from the sinking ship, arrives and saves the day. This is a rescue. Asthma is characterised by episodes of acutely worsening airflow, secondary to bronchospasm. An(More)
In immunocompetent patients with community acquired pneumonia, as well as in the immunocompe-tent host with nosocomial pneumonia, a calculated therapy can be initiated without prior invasive diagnostic procedure. This kind of patient management, however, is not warranted in immunocompromised or immunodeficient patients, in whom an exact diagnosis and the(More)
BACKGROUND The identification of gene-by-environment interactions is important for understanding the genetic basis of chronic obstructive pulmonary disease (COPD). Many COPD genetic association analyses assume a linear relationship between pack-years of smoking exposure and forced expiratory volume in 1 s (FEV(1)); however, this assumption has not been(More)
# Clinical management guidelines have made an invaluable contribution in many areas of medicine. By providing recommendations based on an expert assessment of the available evidence, guidelines can identify "best practice" approaches, help drive consistent quality of care, reduce morbidity and mortality, and improve cost-effectiveness. The considerable(More)
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