Steven G Sethofer

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Polycyclization reactions of unsaturated molecules allow for the rapid construction of complex structures in a single operation. 1 Thus, numerous methods that proceed with excellent diastereose-lectivity have been developed over the past 50 years. 2 In contrast, enantioselective variants are rare and the majority of reported examples involve cyclization(More)
The gold(I)-catalyzed cycloisomerization of enynes containing an embedded cyclopropane unit leads selectively to the formation of ring systems containing the cyclopropylmethyl cation. A subsequent Wagner-Merwein shift provides diastereomerically pure fused cyclobutanes. The utility of this methodology for the rapid assembly of polycyclic ring systems is(More)
Cyclic peptide natural products have evolved to exploit diverse protein targets, many of which control essential cellular processes. Inspired by a series of cyclic peptides with partially elucidated structures, we designed synthetic variants of ternatin, a cytotoxic and anti-adipogenic natural product whose molecular mode of action was unknown. The new(More)
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