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OBJECTIVE To determine the IVF outcome in women over the age of 44 years. DESIGN Retrospective analysis. SETTING University-based IVF center. PATIENT(S) Two hundred eighty-eight consecutive IVF cycles in women over the age of 44 years. INTERVENTION(S) IVF. MAIN OUTCOME MEASURE(S) Ovarian response and cycle outcome. RESULTS The mean age of the(More)
OBJECTIVE To determine the influence of body mass index (BMI) on in vitro fertilization (IVF) outcome by studying a large cohort of good-prognosis IVF patients. STUDY DESIGN This was a retrospective study at a university-based IVF center evaluating 920 good-prognosis patients (< 40 years, all with normal ovarian reserve) undergoing luteal leuprolide(More)
BACKGROUND Studies have suggested that ultrasound-guided embryo transfer (UG-ET) may improve the outcome in IVF; however, several factors may account for the improvement in pregnancy rate. This study examines the use of ultrasound to determine the accuracy of trial transfer (TT) in preparation for ET. METHODS Sixty-seven consecutive patients prospectively(More)
Heat shock proteins (HSP) were first identified in cells after exposure to elevated temperature. Subsequently HSP have been identified as a critical component of a very complex and highly conserved cellular defence mechanism to preserve cell survival under adverse environmental conditions. HSP are preferentially expressed in response to an array of insults,(More)
OBJECTIVE To analyze IVF outcomes in patients with a history of one or more elevations in basal FSH who have a normal basal FSH at the start of their IVF cycle, compared with the general IVF population. DESIGN Retrospective clinical study. SETTING University hospital. PATIENT(S) General IVF patient population. INTERVENTION(S) Patients received(More)
The purpose of this study was to investigate any influence of maternal and/or paternal age on gamete characteristics and pregnancy outcomes in intracytoplasmic sperm injection (ICSI) cycles. In all, 821 consecutive ICSI cases were analysed retrospectively. While a significant linear decline in semen volume was detected, no significant differences in the(More)
OBJECTIVE To determine the fetal loss rate after documented fetal cardiac activity (7-week sonogram) and to evaluate the chromosomal makeup of these losses in IVF pregnancies. DESIGN Retrospective analysis. SETTING University-based IVF center. PATIENT(S) Two thousand fourteen consecutive IVF pregnancies with documented fetal cardiac activity. MAIN(More)
When cells are subjected to various stress factors, they increase the production of a group of proteins called heat shock proteins (hsp). Heat shock proteins are highly conserved proteins present in organisms ranging from bacteria to man. Heat shock proteins enable cells to survive adverse environmental conditions by preventing protein denaturation. Thus(More)
PROBLEM To determine whether granulocyte macrophage (GM)-colony stimulating factor (CSF) produced by autologous endometrial co-culture was associated with outcome in 53 patients with a history of multiple in vitro fertilization failures. METHOD OF STUDY The conditioned media from endometrial co-culture cells exposed or non-exposed to human embryos was(More)
PROBLEM To determine if LIF produced by autologous endometrial co-culture (ECC) was associated with outcome in 46 patients with a history of multiple IVF failures. METHOD OF STUDY The conditioned media (CM) from ECC cells exposed or non-exposed to human embryos was analyzed for LIF. RESULTS Exposure or non-exposure to an embryo did not result in(More)