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OBJECTIVE To determine the influence of body mass index (BMI) on in vitro fertilization (IVF) outcome by studying a large cohort of good-prognosis IVF patients. STUDY DESIGN This was a retrospective study at a university-based IVF center evaluating 920 good-prognosis patients (< 40 years, all with normal ovarian reserve) undergoing luteal leuprolide(More)
The purpose of this study was to investigate any influence of maternal and/or paternal age on gamete characteristics and pregnancy outcomes in intracytoplasmic sperm injection (ICSI) cycles. In all, 821 consecutive ICSI cases were analysed retrospectively. While a significant linear decline in semen volume was detected, no significant differences in the(More)
Heat shock proteins (HSP) were first identified in cells after exposure to elevated temperature. Subsequently HSP have been identified as a critical component of a very complex and highly conserved cellular defence mechanism to preserve cell survival under adverse environmental conditions. HSP are preferentially expressed in response to an array of insults,(More)
OBJECTIVE To determine the fetal loss rate after documented fetal cardiac activity (7-week sonogram) and to evaluate the chromosomal makeup of these losses in IVF pregnancies. DESIGN Retrospective analysis. SETTING University-based IVF center. PATIENT(S) Two thousand fourteen consecutive IVF pregnancies with documented fetal cardiac activity. MAIN(More)
PROBLEM To determine whether granulocyte macrophage (GM)-colony stimulating factor (CSF) produced by autologous endometrial co-culture was associated with outcome in 53 patients with a history of multiple in vitro fertilization failures. METHOD OF STUDY The conditioned media from endometrial co-culture cells exposed or non-exposed to human embryos was(More)
OBJECTIVE To determine the IVF outcome in women over the age of 44 years. DESIGN Retrospective analysis. SETTING University-based IVF center. PATIENT(S) Two hundred eighty-eight consecutive IVF cycles in women over the age of 44 years. INTERVENTION(S) IVF. MAIN OUTCOME MEASURE(S) Ovarian response and cycle outcome. RESULTS The mean age of the(More)
PROBLEM To determine if LIF produced by autologous endometrial co-culture (ECC) was associated with outcome in 46 patients with a history of multiple IVF failures. METHOD OF STUDY The conditioned media (CM) from ECC cells exposed or non-exposed to human embryos was analyzed for LIF. RESULTS Exposure or non-exposure to an embryo did not result in(More)
OBJECTIVE To simulate the in vivo model in studying the effect of hydrosalpinx fluid on embryonic development. DESIGN Controlled prospective study. SETTING Academic research center. PATIENT(S) Five hundred eighty-seven two-cell murine embryos. INTERVENTION(S) Embryos were grown under two sets of conditions. Half were cultured using 10% fetal calf(More)
OBJECTIVE To investigate the prevalence of bacterial vaginosis (BV) and abnormal bacterial vaginal flora in an infertile population and correlate with cervical cytokine production and in vitro fertilization (IVF) outcome. STUDY DESIGN In a blinded study, 331 asymptomatic IVF patients were evaluated for BV, abnormal vaginal flora and cervical cytokine(More)
OBJECTIVE To evaluate serum insulin-like growth factor I (IGF-I) and IGF-binding protein 3 (IGFBP-3) levels during stimulation in polycystic ovary syndrome (PCOS) and control populations as factors predictive of IVF outcome. DESIGN Observational study. SETTING Academic medical center-based IVF practice. PATIENT(S) Forty-three PCOS and 33 male-factor(More)