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  • Steven D Chessler, Åke Lernmark
  • Biology, Medicine
  • The Journal of biological chemistry
  • 2000 (First Published: 18 February 2000)
  • Two forms of glutamic-acid decarboxylase (GAD) have been identified in mammalian tissues: a 65-kDa form (GAD65) and a 67-kDa form (GAD67). Alternate splicing produces one or two smaller variants ofContinue Reading
  • Steven D Chessler, Peter H Byers
  • Biology, Medicine
  • The Journal of biological chemistry
  • 1993 (First Published: 25 August 1993)
  • Of 20 fibroblast cell strains from patients with osteogenesis imperfecta (OI), a disease caused by mutations in the genes encoding type I procollagen, three had increased synthesis of BiP (GRP78), anContinue Reading
  • Arthur T. Suckow, Davide Comoletti, +4 authors Steven D Chessler
  • Biology, Medicine
  • Endocrinology
  • 2008 (First Published: 1 December 2008)
  • The composition of the beta-cell exocytic machinery is very similar to that of neuronal synapses, and the developmental pathway of beta-cells and neurons substantially overlap. beta-Cells secreteContinue Reading
  • Steven D Chessler, Peter H Byers
  • Chemistry, Medicine
  • The Journal of biological chemistry
  • 1992 (First Published: 15 April 1992)
  • We have studied the folding, processing, and association with two endoplasmic reticulum (ER) resident proteins of the abnormal type I procollagen molecules produced by a strain of fibroblastsContinue Reading
  • Shireen R Lamandé, Steven D Chessler, +5 authors John F Bateman
  • Biology, Medicine
  • The Journal of biological chemistry
  • 1995 (First Published: 14 April 1995)
  • A heterozygous single base change in exon 49 of COL1A1, which converted the codon for pro alpha 1(I) carboxyl-terminal propeptide residue 94 from tryptophan (TGG) to cysteine (TGT) was identified inContinue Reading
  • Steven D Chessler, William T. N. Simonson, Ian R Sweet, Lisa P. Hammerle
  • Biology, Medicine
  • Diabetes
  • 2002 (First Published: 1 June 2002)
  • gamma-Aminobutyric acid (GABA) is stored in microvesicles in pancreatic islet cells. Because GAD65 and GAD67, which catalyze the formation of GABA, are cytoplasmic, the existence of an isletContinue Reading