Steven Colburn

Learn More
In order to get a systematic picture of how various hearing impairments and neurologic disorders may affect sound localization, psychophysical spatial- and lateralization-discrimination measurements were performed on 140 subjects, including 69 with different types of hearing impairments, 32 with neurological diseases, and 39 with normal hearing. The(More)
We present a model for tone-in-noise detection at low frequencies that includes a physiologically realistic mechanism for processing the information in neural discharge times. The proposed model exploits the frequency-dependent phase properties of the tuned filters in the auditory periphery and uses cross-auditory-nerve-fiber coincidence detection to(More)
The neuropeptide vasoactive intestinal peptide (VIP) is expressed in several distinct sites in the CNS, in cholinergic and enteric ganglia, and in a small subpopulation of neurons within sympathetic ganglia. Previous studies on the human VIP gene indicate that transcription in neural crest-derived neuroblastoma and pheochromocytoma cell lines is controlled(More)
Neuronal differentiation was induced in cultures of the human neuroblastoma cell line subclone SH-SY5Y by 14-day treatment with dibutyryl cAMP (dBcAMP), retinoic acid, and phorbol 12-myristate 13-acetate (PMA). An approximate 4-fold increase in vasoactive intestinal peptide (VIP) mRNA concentration was observed after differentiation with retinoic acid,(More)
The effects of recombinant human alpha tumor necrosis factor (alpha-TNF) were compared with those of cytotoxic serum from patients with the acute Guillain-Barré syndrome (GBS) in myelinated cultures containing only rat Schwann cells and dorsal root ganglion neurons. Alpha-TNF did not damage rat peripheral nervous system tissue in culture. These observations(More)
Over the last few years, music fans have filmed portions of live concerts on their mobile phones or compact video cameras and upload this footage to YouTube. This article focuses on what motivates " filmers " to place a camera between themselves and the performance on stage to capture footage consumed later. A notable facet of the culture of concert filming(More)
Sound source lateralization can be accomplished in many real world environments with a simple cross-correlation model. The precedence effect predicts that in certain situations, such as sounds with a single loud reflection, sound source lateralization performance of normal hearing listeners could be better than performance predicted by a simple(More)