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To determine the incidence of adverse drug reactions (ADRs) to unlicensed and off-label drugs used in paediatric inpatients, we carried out prospective surveillance on five different paediatric wards in a regional children's hospital for 13 wk. Comparison of the use of each drug with its summary of product characteristics was made to determine whether the(More)
OBJECTIVE To determine the extent of use in children in hospital of drugs that are not specifically licensed for use in children (unlicensed) and of drugs that are used outside the terms of their product licence that apply to indication, age, dose, or route of administration (off label). DESIGN Prospective study of drugs administered on paediatric medical(More)
The production of hydrogen from substrates and substrate mixture of sugar alcohols and Polydextrose was determined, both in vivo using the breath hydrogen test, and in vitro, using human faecal microorganisms in anaerobic culture. One objective was to test a previous assumption that the stoichiometry of hydrogen production from different alternative(More)
OBJECTIVE To compare the cost of using intravenous epoprostenol with that of inhaled nitric oxide (NO) for treating episodes of pulmonary hypertension in children with congenital heart disease. DESIGN An analysis of the cost of epoprostenol and NO use over the previous 18 months was performed. Three 6-month periods were identified, two in which(More)
tEVOH = ethylene-vinyl alcohol copolymer; SMA = styrene-maleic anhydride copolymer Republication or reproduction of this report or its storage and/or dissemination by electronic means is permitted without the need for formal IUPAC permission on condition that an acknowledgement, with full reference to the source along with use of the copyright symbol 0, the(More)
This study applies a Bayesian methodology to the oft-examined issue of whether a structural change has occurred in U .S. meat demand. The Bayesian approach allows us several advantages over earlier studies. First, we can estimate the true AIDS model instead of the commonly substituted linear-approximate version. Second, we derive the marginal posterior(More)
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