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The generation of tissue factor coagulant activity was measured in short-term cultures of mixed mononuclear cells prepared from peripheral blood. Levels of tissue factor activity were significantly increased (P less than 0.05) at 3 and 7 days after surgery in patients who had had uncomplicated surgical procedures when comparison was made with preoperative… (More)
Thrombotic thrombocytopenic purpura (TTP) occurred in a young woman during the ninth month of an uneventful pregnancy. At birth, the infant was asymptomatic, with a platelet count of 160,000/cu mm. Repeated examinations of the infant's peripheral blood film have shown normal platelet estimates and no fragmented erythrocytes. These findings support the… (More)
Nafazatrom (Bay g 6575) has been shown to be a potent inhibitor of tumor metastasis in preclinical models. It is believed to work by stimulating endogenous prostacyclin production. The drug has also been shown to inhibit the growth of certain experimental tumors, to be cytostatic for certain cell lines in tissue culture, and to induce differentiation in… (More)
The reduction of nitroblue tetrazolium (NBT) by phagocytic leucocytes in peripheral blood has been examined in rabbits injected intratesticularly with Treponema pallidum, T. pallidum-free supernatant of orchitic testes, or normal rabbit testes supernatant. A significant (P less than 0.01) increase in NBT reduction was observed only in the infected animals.