Chondrogenic differentiation of mesenchymal cells is generally thought to be initiated by the inductive action of specific growth factors and depends on intimate cell-cell interactions. In this… (More)
Formation of cartilage during both embryonic development and repair processes involves the differentiation of multipotential mesenchymal cells. The mouse cell line, C3H10T1/2, has been shown to be… (More)
Applied electric fields (static and pulsing) are widely used in orthopedic practices to treat nonunions and spine fusions and have been shown to improve ligament healing in vivo. Few studies,… (More)
Back pain is a significant clinical concern often associated with degeneration of the intervertebral disc (IVD). Tissue engineering strategies may provide a viable IVD replacement therapy; however,… (More)
The spine journal : official journal of the North…
2013
BACKGROUND CONTEXT
Degeneration and injuries of the intervertebral disc (IVD) result in large alterations in biomechanical behaviors. Repair strategies using biomaterials can be optimized based on… (More)
Biological integration of cartilage grafts with subchondral bone remains a significant clinical challenge. We hypothesize that interaction between osteoblasts and chondrocytes is important in… (More)
AIMS
To develop a rat model of temporomandibular joint (TMJ) pain and to characterize in it the development and temporal response of behavioral hypersensitivity as well as to evaluate if and to what… (More)
Under physiological conditions of loading, articular cartilage is subjected to both compressive strains, normal to the articular surface, and tensile strains, tangential to the articular surface.… (More)
Intervertebral disc (IVD) degeneration is a significant health concern in the USA. Tissue engineering strategies have the potential to provide a viable alternative to current treatments.… (More)
Hyaluronan, a high-molecular-weight glycosaminoglycan of cartilage, is deposited directly into the extracellular space by hyaluronan synthases, while hyaluronan catabolism is mediated by the… (More)