Steven B. Flynn

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A number of agents that mimic the ability of the thyroid hormone, T3, to decrease plasma cholesterol levels are described; one is as effective as T3 at reducing cholesterol levels and stimulating liver function, but has very little effect on cardiac function and is thus less likely to be toxic. The agent may be useful in the treatment of atherosclerosis.
1. The vasodilator activity of histamine has been studied in anaesthetized cats. 2. Histamine causes dose-dependent vasodilatation in the vasculature of the hind-limb and mesentery, perfused with blood at constant flow. 3. Experiments using the selective antagonists mepyramine and metiamide indicate the involvement of both H1- and H2-receptors in the(More)
1 Differentiation of the roles of histamine H1- and H2-receptors in the mediation of the effects of histamine on the isolated working heart of the guinea-pig was achieved through the use of histamine and selective histamine receptor agonists and antagonists. 2 Histamine over the dose range 10(-9) mol to 10(-6) mol produced dose-related increases in sinus(More)
We investigated the changes in cardiac function following alterations in thyroid state of rats, using the isolated working heart preparation. This technique allows heart rate, contractility, and pump function to be studied under controlled conditions. Surgical thyroidectomy resulted in significant impairment of cardiac function. Single doses of(More)
1 The cardiovascular responses to dimaprit (S-(3-dimethylaminopropyl) isothiourea) a selective histamine H2-receptor agonist have been studied in anaesthetized cats, dogs, rats and rabbits. 2 Dimaprit lowered systemic arterial blood pressure in all species whether given by intravenous injection or by continous infusion. Intra-arterial injections or(More)
cur within a subretinal mass in Coats disease. To our knowledge, this is the first report of intraretinal calcification in Coats disease. Intraretinal calcification classically occurs in retinoblastoma; however, it may also be detected in retinocytoma, tuberous sclerosis, and epiretinal membranes. This case reinforces the importance of a complete ophthalmic(More)
PURPOSE To document reversible corneal edema caused by amantadine in a pediatric patient. METHODS A 14-year-old boy with a neurologic tremor was referred for bilateral visual loss. Our examination disclosed bilateral corneal edema without ocular inflammation. Pachymetry confirmed significantly increased corneal thickness above 900 microm. RESULTS Review(More)