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OBJECTIVE An abnormality of the optical transmission waveform obtained during measurement of the activated partial thromboplastin time (aPTT) has been described in association with overt disseminated intravascular coagulation. This abnormality, a biphasic waveform, is caused by the in vitro formation of Ca2+-induced complexes between very low density(More)
BACKGROUND The pharmacokinetic (PK) interaction between ritonavir-boosted elvitegravir (elvitegravir/r) and maraviroc was evaluated. METHODS Healthy subjects were randomized to receive elvitegravir/r (150/100 mg once daily) before or after elvitegravir/r plus maraviroc (150 mg twice daily) (group 1; n = 20) or receive maraviroc before or after maraviroc(More)
TCP protocol has been designed and tuned to perform well on wired network where the packet loss is due mainly to congestion. On heterogeneous networks where some links can be wireless this assumption is no more valid. In this paper, we propose a protocol which makes the TCP protocol layer aware of high bit error rates on wireless links while it tries to(More)
Determining the geochemistry in the remote hostile Martian environment requires sensors specifically designed to meet such a unique challenge. We report here on the initial development, considerations, and a prototype array of electrochemical sensors for measuring in-situ a variety of ionic species in the Martian soil (regolith). The sensor array consists(More)
OBJECTIVE This study evaluated the relative bioavailability and pharmacokinetics of elvitegravir (EVG), emtricitabine (FTC), tenofovir disoproxil fumarate (TDF), and a investigational pharmacoenhancer, cobicistat (GS-9350, COBI) coformulated as a fixed-dose combination tablet (FDC) compared with ritonavir-boosted EVG and FTC + TDF in healthy subjects. (More)
New evidence indicates that termination of transcription is an important regulatory step, closely related to transcriptional interference and even transcriptional initiation. However, how this occurs is poorly understood. Recently, in vivo analysis of transcriptional termination for the human beta-globin gene revealed a new phenomenon--co-transcriptional(More)
BACKGROUND This crossover, open-label clinical study evaluated the potential for clinically relevant drug interactions between ritonavir-boosted elvitegravir (elvitegravir/r), an HIV integrase inhibitor, and etravirine, a non-nucleoside reverse transcriptase inhibitor. METHODS Healthy volunteers were randomized into one of two groups, each with two arms.(More)
SETTING At the Faculty of Medical Sciences, The University of the West Indies, St Augustine first-year students take two courses in health communication. In the Centre for Medical Sciences Education students completed a course experience questionnaire. This instrument is potentially useful in evaluating innovative programmes and securing support for their(More)
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