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BACKGROUND The spread of resistance to chloroquine (CQ) led to its withdrawal from use in most countries in sub-Saharan Africa in the 1990s. In Malawi, this withdrawal was followed by a rapid reduction in the frequency of resistance to the point where the drug is now considered to be effective once again, just nine years after its withdrawal. In this(More)
The structural similarity index (SSIM) has been shown to be a superior objective image quality metric. A web-based pilot experiment was conducted with the goal of quantifying, through the use of a sample of human participants, a trend in SSIM values showing when the human visual system can begin to perceive distortions applied to reference images. The just(More)
We describe an approach to automate certain high-level implementation decisions in a pervasive application , allowing them to be postponed until run time. Our system enables a model in which an application programmer can specify the behavior of an adaptive application as a set of open-ended decision points. We formalize decision points as Goals, each of(More)
The NuMesh system defines a high-speed communication sub-strate optimized for off-line routing. By determining possible communication paths at compile time, highly efficient hardware and software constructs can be exploited to yield superior network performance. These communication paths can be independently tuned to allow more utilized paths greater(More)
  • Julie A Simpson, Tsiri Agbenyega, Karen I Barnes, Gianni Di Perri, Peter Folb, Melba Gomes +19 others
  • 2006
BACKGROUND Intra-rectal artesunate has been developed as a potentially life-saving treatment of severe malaria in rural village settings where administration of parenteral antimalarial drugs is not possible. We studied the population pharmacokinetics of intra-rectal artesunate and the relationship with parasitological responses in patients with moderately(More)
Many standardized hardware communication interfaces offer run-time flexibility and configurability at the cost of efficiency. An alternate approach is the use of a highly-efficient, minimal communication element, with as much communication decision-making as possible done at compile time. NuMesh is a packaging and interconnect technology supporting(More)
— The rapid increase in the number and variety of consumer-level electronic devices without the corresponding development of device management technology has lead to a configuration nightmare. We propose to use goal-oriented programming over a substrate of network-portable objects to help reduce the amount of configuration users must do in order to have(More)