Steve Ugent

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many cell types including fibroblasts and keratinocytes, tacrolimus acts specially on inflammatory cells. The mechanism of action is unknown, but it may be exerted through the inhibition of interleukin-2 primarily and interferon-c secondarily, factors that have been found in abundance in granulomatous tissue patients. One of the major immunomodulating(More)
The chemical synthesis of riboflavin 5'-phosphorothioate (5'-FMNS) is described. 5'-FMNS is obtained from the alkaline hydrolysis of riboflavin 4',5'-cyclic phosphorothioate, which is produced upon reaction of riboflavin (RB) with thiophosphoryl chloride in trimethyl phosphate. 5'-FMNS has been tested for enzymatic reconstitution of NADPH-cytochrome P-450(More)
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