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First- and second-generation sequencing technologies have led the way in revolutionizing the field of genomics and beyond, motivating an astonishing number of scientific advances, including enabling a more complete understanding of whole genome sequences and the information encoded therein, a more complete characterization of the methylome and transcriptome(More)
Optical approaches for observing the dynamics of single molecules have required pico- to nanomolar concentrations of fluorophore in order to isolate individual molecules. However, many biologically relevant processes occur at micromolar ligand concentrations, necessitating a reduction in the conventional observation volume by three orders of magnitude. We(More)
OBJECTIVE To test the effectiveness of educational interventions in improving detection rates and management of dementia in primary care. DESIGN Unblinded, cluster randomised, before and after controlled study. SETTING General practices in the United Kingdom (central Scotland and London) between 1999 and 2002. INTERVENTIONS Three educational(More)
We develop a discrete model of malignant invasion using a thermodynamic argument. An extension of the Potts model is used to simulate a population of malignant cells experiencing interactions due to both homotypic and heterotypic adhesion while also secreting proteolytic enzymes and experiencing a haptotactic gradient. In this way we investigate the(More)
BACKGROUND Increasing evidence suggests that patterns of T-cell immunity to inhalant allergens in genetically diverse human populations are more heterogeneous than previously assumed, and that covert differences in expression patterns might underlie variations in airway disease phenotypes. We tested this proposition in a community sample of children. (More)
INTRODUCTION The health effects on young children of exposure to secondhand smoke (SHS) are well described. Recent work suggests that over one quarter of school-aged children in Scotland are regularly exposed to SHS in the home. The study was designed to describe SHS exposure in preschool children whose mothers smoked and identify factors that influence(More)
BACKGROUND Studies of the academic progress of schoolchildren with Down's syndrome have given only limited indication of attainments at different ages. Such normative data, it is argued, could guide professionals and parents in respect to reasonable expectations and typical achievement. AIMS The aim of the paper is to provide a descriptive account of(More)
BACKGROUND There is a lack of data describing the exposure of Malaysian schoolchildren to Secondhand Smoke (SHS). The aim of this study is to identify factors influencing schoolchildren's exposures to SHS in Malaysia. METHOD This cross-sectional study was carried out to measure salivary cotinine concentrations among 1064 schoolchildren (10-11 years)(More)
OBJECTIVE Our purpose was to determine maternal and fetal outcome in patients undergoing surgery for pelvic mass in pregnancy. STUDY DESIGN Maternal and fetal records of 130 cases of adnexal masses associated with intrauterine pregnancy that required laparotomy or aspiration or that were diagnosed incidentally at the time of cesarean section were(More)
BACKGROUND AND AIMS We have previously shown an association between reduced premorbid lung function (V'maxFRC) and bronchiolitis. We hypothesised that individuals with bronchiolitis will go on to have reduced lung function and increased respiratory symptoms in childhood. METHODS V'maxFRC was measured at 1 month of age; individuals with bronchiolitis were(More)