Learn More
First- and second-generation sequencing technologies have led the way in revolutionizing the field of genomics and beyond, motivating an astonishing number of scientific advances, including enabling a more complete understanding of whole genome sequences and the information encoded therein, a more complete characterization of the methylome and transcriptome(More)
Chickpea and white lupin roots are able to exude large amounts of carboxylates, but the resulting concentrations in the rhizosphere vary widely. We grew chickpea in pots in eleven different Western Australian soils, all with low phosphorus concentrations. While final plant mass varied more than two-fold and phosphorus content almost five-fold, there were(More)
Optical approaches for observing the dynamics of single molecules have required pico- to nanomolar concentrations of fluorophore in order to isolate individual molecules. However, many biologically relevant processes occur at micromolar ligand concentrations, necessitating a reduction in the conventional observation volume by three orders of magnitude. We(More)
Tuning supercomputer application performance often requires analyzing the interaction of the application and the underlying architecture. In this paper, we describe support in the MIPS R10000 for non-intrusively monitoring a variety of processor events -- support that is particularly useful for characterizing the dynamic behavior of multi-level memory(More)
BACKGROUND Increasing evidence suggests that patterns of T-cell immunity to inhalant allergens in genetically diverse human populations are more heterogeneous than previously assumed, and that covert differences in expression patterns might underlie variations in airway disease phenotypes. We tested this proposition in a community sample of children. (More)
OBJECTIVE To measure general practitioners' knowledge of, confidence with and attitudes to the diagnosis and management of dementia in primary care. SETTING 20 general practices of varying size and prior research experience in Central Scotland, and 16 similarly varied practices in north London. PARTICIPANTS 127 general practitioners who had volunteered(More)
OBJECTIVE To test the effectiveness of educational interventions in improving detection rates and management of dementia in primary care. DESIGN Unblinded, cluster randomised, before and after controlled study. SETTING General practices in the United Kingdom (central Scotland and London) between 1999 and 2002. INTERVENTIONS Three educational(More)
BACKGROUND Maternal intake of vitamin D in pregnancy is a potentially modifiable but understudied risk factor for the development of asthma in children. OBJECTIVE We investigated whether maternal vitamin D intake in pregnancy is associated with decreased risks of wheezing symptoms in young children. DESIGN Subjects were from a birth cohort recruited in(More)
We develop a discrete model of malignant invasion using a thermodynamic argument. An extension of the Potts model is used to simulate a population of malignant cells experiencing interactions due to both homotypic and heterotypic adhesion while also secreting proteolytic enzymes and experiencing a haptotactic gradient. In this way we investigate the(More)
BACKGROUND Exhaled nitric oxide (FE(NO)) is raised in asthmatic children, but there are inconsistencies in the relationship between FE(NO) and characteristics of asthma, including atopy, increased airway responsiveness (AR), and airway inflammation. The aim of this study was to investigate the relationship between FE(NO) and asthma, atopy, and increased AR(More)