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Journals and Conferences
While intelligent environments are often cited as a reason for doing work on visual person-tracking, really making an intelligent environment exposes many real-world problems in visual tracking that must be solved to make the technology practical. In the context of our EasyLiving project in intelligent environments, we created a practical person-tracking… (More)
Computational tools can markedly accelerate the rate at which murine genetic models can be analyzed. We developed a computational method for mapping phenotypic traits that vary among inbred strains onto haplotypic blocks. This method correctly predicted the genetic basis for strain-specific differences in several biologically important traits. It was also… (More)
Combining the experimental efficiency of a murine hepatic in vitro drug biotransformation system with in silico genetic analysis produces a model system that can rapidly analyze interindividual differences in drug metabolism. This model system was tested by using two clinically important drugs, testosterone and irinotecan, whose metabolism was previously… (More)
Pharmacogenetic approaches can be instrumental for predicting individual differences in response to a therapeutic intervention. Here we used a recently developed murine haplotype-based computational method to identify a genetic factor regulating the metabolism of warfarin, a commonly prescribed anticoagulant with a narrow therapeutic index and a large… (More)
EasyLiving is a new project in intelligent environments at Microsoft Research. We are working to make computing more accessible and more pervasive than today's desktop computer. More specifically, our goal is to develop a prototype architecture and technologies for building intelligent environments that facilitate the unencumbered interaction of people with… (More)
ADAGE is a project to define and build a domain-specific software architecture (DSSA) environment for assisting the development of avionics software. A central concept of DSSA is the use of software system generators to implement component-based models of software synthesis in the target domain [SEI90]. In this paper, we present the ADAGE component-based… (More)
Perception is a vital part of a smart environment, both as a way to sense the state of the space and a way to detect commands from its users. This paper catalogs different sorts of perception for smart environments using the EasyLiving project at Microsoft Research as the main example.
Computational haplotype-based genetic mapping can be used to discover new biological mechanisms, disease-related pathways, and unexpected uses for existing drugs. Here we discuss the benefits and limitations of this methodology, its impact on translational medicine, and its future course.
Analysis of mouse genetic models of human disease-associated traits has provided important insight into the pathogenesis of human disease. As one example, analysis of a murine genetic model of osteoporosis demonstrated that genetic variation within the 15-lipoxygenase (Alox15) gene affected peak bone mass, and that treatment with inhibitors of this enzyme… (More)