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The first chordates appear in the fossil record at the time of the Cambrian explosion, nearly 550 million years ago. The modern ascidian tadpole represents a plausible approximation to these ancestral chordates. To illuminate the origins of chordate and vertebrates, we generated a draft of the protein-coding portion of the genome of the most studied(More)
Optical mapping and nanocoding are single molecule restriction mapping systems for interrogating genomic structure at a scale that cannot currently be achieved using DNA sequencing methods. In these mapping experiments, large DNA molecules ≈ 500 kb are stretched, immobilized or confined, and then digested with a restriction endonuclease that cuts or nicks(More)
Sexually reproducing organisms produce two very different phenotypes (males and females), by differential deployment of essentially the same gene content. This dimorphism provides an excellent model to study how transcriptomes are differentially regulated, which is one of the central problems of biology. The core sex determination pathway of Drosophila is a(More)
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