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Peripheral pain pathways are activated by a range of stimuli. We used diphtheria toxin to kill all mouse postmitotic sensory neurons expressing the sodium channel Nav1.8. Mice showed normal motor activity and low-threshold mechanical and acute noxious heat responses but did not respond to noxious mechanical pressure or cold. They also showed a loss of(More)
Human monogenic pain syndromes have provided important insights into the molecular mechanisms that underlie normal and pathological pain states. We describe an autosomal-dominant familial episodic pain syndrome characterized by episodes of debilitating upper body pain, triggered by fasting and physical stress. Linkage and haplotype analysis mapped this(More)
Twenty-nine couples with an average of 5 years of infertility were selected for treatment by intrauterine insemination of washed semen (AIH). The criteria for selection were (i) the female partner showed no detectable fertility disorders by routine screening; (ii) the male partner showed subnormal semen quality on conventional semen analysis. Ovulation was(More)
The effect of morphology on the ability of human spermatozoa to penetrate zona-free hamster oocytes was investigated using fractions of individual semen samples enriched for morphologically normal or abnormal spermatozoa, after separation by buoyant density centrifugation on self-generating Percoll gradients. Using this separation technique, the percentage(More)
Executive Summary Privacy is a hot topic – one that enterprises ignore at their peril. A stronger legal and regulatory environment, high profile privacy failures, and increasing public concerns build the case for enterprises to take privacy seriously. For those new to the subject, this paper describes the harms that privacy failures can lead to, and the(More)
The world is changing, and Agents seem to be on everyone's lips. The world is changing, collaborative technologies and collaboration in general, especially across distance, is becoming more and more important. Combining the power of autonomous, pseudo-intelligent agents and collaborative systems is not only a good idea, we think it's vital to making the(More)