• Publications
  • Influence
Absence of putative artemisinin resistance mutations among Plasmodium falciparum in Sub-Saharan Africa: a molecular epidemiologic study.
TLDR
An assay to quantify rare polymorphisms in parasite populations that uses a pooled deep-sequencing approach to score allele frequencies is developed and validated by evaluating mixtures of laboratory parasite strains, and used to screen P. falciparum parasites from >1100 African infections collected since 2002. Expand
Neurologic complications of cerebral angiography: prospective analysis of 2,899 procedures and review of the literature.
TLDR
Age-related vascular disease accounted for the failure to lower the neurologic complication rate of cerebral angiography despite technical advances. Expand
Haemoglobinopathies and the clinical epidemiology of malaria: a systematic review and meta-analysis.
TLDR
Haemoglobin AS, CC, and AC genotypes and homozygous and heterozygous α-thalassaemia provide significant protection from severe malaria syndromes, but these haemoglobinopathies differ substantially in the degree of protection provided and confer mild or no protection against uncomplicated malaria and asymptomatic parasitaemia. Expand
Comparison of real-time PCR and microscopy for malaria parasite detection in Malawian pregnant women
TLDR
Although microscopy remains the most appropriate method for clinical malaria diagnosis in field settings, molecular diagnostics such as real-time PCR offer a more reliable means to detect malaria parasites, particularly at low levels. Expand
High-Throughput Pooling and Real-Time PCR-Based Strategy for Malaria Detection
TLDR
This study describes the application of a resource-conserving testing algorithm employing sample pooling for real-time PCR assays for malaria in a cohort of 182 pregnant women in Kinshasa and highlights both substantial discordance between malaria diagnostics and the utility and parsimony of employing a sample Pooling strategy for molecular diagnostics in clinical and epidemiologic malaria studies. Expand
Artemisinin resistance in Plasmodium falciparum malaria.
TLDR
The absence of an increased 50% inhibitory concentration in vitro, molecular evidence of resistance, or a clear association between the parasite clearance time and clinical response suggest that clinically relevant artemisinin resistance has not emerged in Pailin. Expand
Population, behavioural and environmental drivers of malaria prevalence in the Democratic Republic of Congo
TLDR
This study provides the most accurate population-based estimates to date of where illness from malaria occurs in the D Congo and what factors contribute to the estimated spatial patterns, and suggests that spatial information and analyses can enable the DRC government to focus its control efforts against malaria. Expand
Burden, pathology, and costs of malaria in pregnancy: new developments for an old problem.
TLDR
This Series paper summarises recent progress and highlights unresolved issues related to the burden of malaria in pregnancy and suggests pregnant women could be used to monitor malaria transmission. Expand
Quantification of the burden and consequences of pregnancy-associated malaria in the Democratic Republic of the Congo.
TLDR
Extrapolation of the prevalence estimate to the population at risk of malaria in DRC suggests 1.015 million births are affected by P falciparum infection annually, and that adherence to preventive measures could prevent up to 549 000 episodes of pregnancy-associated malaria and 47 000 low-birth-weight births. Expand
Hemoglobinopathies: Slicing the Gordian Knot of Plasmodium falciparum Malaria Pathogenesis
TLDR
Hemoglobinopathies slice the “Gordian knot” of host and parasite interactions to confer malaria protection, and offer a translational model to identify the most critical mechanisms of P. falciparum pathogenesis. Expand
...
1
2
3
4
5
...