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Noisy ceramics bearing surfaces are a recently recognized problem in total hip arthroplasty. Component malposition as a potential cause has been proposed. Squeaking occurred in 28 (2.7%) of 999 patients undergoing ceramic on ceramic total hip arthroplasty at our institution. Patients were matched, in a 1:2 ratio by anthropometric and demographic variables(More)
In 1998, orthopaedic manufacturers started to introduce highly crosslinked ultra-high molecular weight polyethylene (UHMWPE) for total hip replacement bearings. Today's highly-crosslinked UHMWPEs materials are irradiation processed with a total dose ranging between 50 and 105 kGy, depending upon the manufacturer. Each manufacturer has adopted a different(More)
There is considerable interest in characterization of wear debris from polyethylene (UHMWPE) bearing components used in total joint replacement. To isolate UHMWPE wear debris, tissue samples must be excised from regions adjacent to revised UHMWPE implant components, followed by exposure to one of many available tissue digestion methods. Numerous studies(More)
BACKGROUND Revision THA and TKA are growing and important clinical and economic challenges. Healthcare systems tend to combine revision joint replacement procedures into a single service line, and differences between revision THA and revision TKA remain incompletely characterized. These differences carry implications for guiding care and resource(More)
The purpose of this study is to compare the differences in downstream cost and health outcomes between Medicare hip OA patients who undergo total hip arthroplasty (THA) and those who do not. All OA patients in the Medicare 5% sample (1998-2009) were separated into non-THA and THA groups. Differences in costs and risk ratios for mortality and new disease(More)
Human immunodeficiency virus 1 (HIV-1) encodes a gene product, Vpr, that facilitates the nuclear uptake of the viral pre-integration complex in non-dividing cells and causes infected cells to arrest in the G(2) phase of the cell cycle. Vpr was also shown to cause mitochondrial dysfunction in human cells and budding yeasts, an effect that was proposed to(More)
There are little data that quantify the long term costs, mortality, and downstream disease after Total Knee Arthroplasty (TKA). The purpose of this study is to compare differences in cost and health outcomes between Medicare patients with OA who undergo TKA and those who avoid the procedure. The Medicare 5% sample was used to identify patients diagnosed(More)
Verification and validation (V&amp;V) techniques are used in agent-based modeling (ABM) to determine whether the model is an accurate representation of the real system. Docking is a form of V&V that tries to align multiple simulation models. In a previous paper, we described the docking process of an ABM that simulates the life cycle of <i>Anopheles(More)
Field-coupled nanomagnets can offer significant energy savings at iso-performance versus CMOS equivalents. Magnetic logic could be integrated with CMOS, operate in environments that CMOS cannot, and retain state without power. Clocking requirements lead to inherently pipelined circuits, and high throughput further improves application-level performance.(More)