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  • Alan Kenneth Burnett, Nigel H. Russell, +13 authors David Grimwade
  • Medicine
  • The Lancet. Oncology
  • 2015 (First Publication: 1 October 2015)
  • BACKGROUND Acute promyelocytic leukaemia is a chemotherapy-sensitive subgroup of acute myeloid leukaemia characterised by the presence of the PML-RARA fusion transcript. The present standard of care,Expand
  • Alan Kenneth Burnett, Steve Knapper
  • Medicine
  • Hematology. American Society of Hematology…
  • 2007
  • Currently available chemotherapy has probably reached the limits of its potential in treating acute myeloid leukemia (AML). In considering the next steps it is appropriate to exploit on the one handExpand
  • Naeem Khan, Robert K Hills, +10 authors Sylvie D Freeman
  • Medicine, Biology
  • PloS one
  • 2016 (First Publication: 26 September 2016)
  • In acute myeloid leukemia (AML) quiescence and low oxidative state, linked to BCL2 mitochondrial regulation, endow leukemic stem cells (LSC) with treatment-resistance. LSC in CD34+ and more matureExpand
  • Alan Kenneth Burnett, Emma Das Gupta, +9 authors Nigel H. Russell
  • Medicine
  • Haematologica
  • 2018 (First Publication: 5 July 2018)
  • As part of the UK NCRI AML17 trial, adult patients with acute myeloid leukemia in remission could be randomized to receive the mammalian target of rapamycin inhibitor everolimus, sequentially withExpand
  • Joanna Zabkiewicz, Michelle Lazenby, +8 authors Caroline L Alvares
  • Medicine
  • British journal of haematology
  • 2020 (First Publication: 11 May 2020)
  • Minimal residual disease (MRD) in acute myeloid leukaemia (AML) poses a major challenge due to drug insensitivity and high risk of relapse. Intensification of chemotherapy and stem cellExpand