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- Peter Langfelder, Steve Horvath
- BMC Bioinformatics
- 2008
Correlation networks are increasingly being used in bioinformatics applications. For example, weighted gene co-expression network analysis is a systems biology method for describing the correlation… (More)
- Bin Zhang, Steve Horvath
- Statistical applications in genetics and…
- 2005
Gene co-expression networks are increasingly used to explore the system-level functionality of genes. The network construction is conceptually straightforward: nodes represent genes and nodes are… (More)
- Steve Horvath, Xin Xu, Nan M. Laird
- European Journal of Human Genetics
- 2001
With possibly incomplete nuclear families, the family based association test (FBAT) method allows one to evaluate any test statistic that can be expressed as the sum of products (covariance) between… (More)
- Irina Voineagu, Xinchen Wang, +7 authors Daniel H. Geschwind
- Nature
- 2011
Autism spectrum disorder (ASD) is a common, highly heritable neurodevelopmental condition characterized by marked genetic heterogeneity. Thus, a fundamental question is whether autism represents an… (More)
- Michael C. Oldham, Genevieve Konopka, +4 authors Daniel H. Geschwind
- Nature Neuroscience
- 2008
The enormous complexity of the human brain ultimately derives from a finite set of molecular instructions encoded in the human genome. These instructions can be directly studied by exploring the… (More)
- Michael Hawrylycz, Ed S Lein, +64 authors Allan R. Jones
- Nature
- 2012
Neuroanatomically precise, genome-wide maps of transcript distributions are critical resources to complement genomic sequence data and to correlate functional and genetic brain architecture. Here we… (More)
- Peter Langfelder, Rui Luo, Michael C. Oldham, Steve Horvath
- PLoS Computational Biology
- 2011
In many applications, one is interested in determining which of the properties of a network module change across conditions. For example, to validate the existence of a module, it is desirable to… (More)
- R. Kannama Sridharan, Jason H. Tchieu, +5 authors Kathrin Plath
- Cell
- 2009
Induced pluripotent stem (iPS) cells can be obtained from fibroblasts upon expression of Oct4, Sox2, Klf4, and c-Myc. To understand how these factors induce pluripotency, we carried out genome-wide… (More)
- Ingo K. Mellinghoff, Maria Y. Wang, +21 authors Paul Mischel
- The New England journal of medicine
- 2005
BACKGROUND
The epidermal growth factor receptor (EGFR) is frequently amplified, overexpressed, or mutated in glioblastomas, but only 10 to 20 percent of patients have a response to EGFR kinase… (More)
- Steve Horvath, Jun Dong
- PLoS Computational Biology
- 2008
THE MERGING OF NETWORK THEORY AND MICROARRAY DATA ANALYSIS TECHNIQUES HAS SPAWNED A NEW FIELD: gene coexpression network analysis. While network methods are increasingly used in biology, the network… (More)