Steve Holland

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19F NMR imaging of the perfluorocarbon emulsion Fluosol has been used to study regional variations in oxygen tension in rat liver and spleen. We have used the linear dependence of spin lattice relaxation rate (1/T1) on the partial oxygen pressure (pO2) of Fluosol to determine the oxygen tension in the reticuloendothelial system (RES) of the liver and spleen(More)
Intelligent assist devices (IADs) are a new class of hybrid devices for direct, physical, interaction with a human operator in shared workspaces. These devices – designed for the assembly line worker – can reduce ergonomics concerns that arise due to on-the-job physical and cognitive loading, while improving safety, quality and productivity. Cobots, a(More)
A theoretical description of the nuclear magnetic resonance (NMR) signal from flowing nuclei has been developed for rapid imaging sequences that use small flip angles and gradient refocused echoes. Both laminar and plug flow models have been considered and formulas derived relating mean image signal intensity to flip angle, pulse sequence repetition(More)
We have developed an animal model to elucidate the acute effects of perfusion abnormalities on muscle metabolism induced by different density-defined classes of erythrocytes isolated from sickle cell anemia patients. Technetium-99m (99mTc)-labeled, saline-washed normal (AA), homozygous sickle (SS), or high-density SS (SS4) erythrocytes were injected into(More)
This paper presents the design, fabrication, operating characteristics and applications of a wideband, high-frequency, line-focus beam transducer we constructed using a 9 microm thick piezoelectric polyvinylidene fluoride (PVDF) film. This transducer possesses a focal length of 2.38 mm and an aperture angle of 84 degrees. The frequency spectrum of the(More)
Thick, fully depleted p-channel charge-coupled devices (CCDs) have been developed at the Lawrence Berkeley National Laboratory (LBNL). These CCDs have several advantages over conventional thin, n-channel CCDs, including enhanced quantum efficiency and reduced fringing at nearinfrared wavelengths and improved radiation tolerance. Here we report results from(More)
A position-sensitive detector chamber is introduced for the three-dimensional (3D) dosimetry of photon-emitting brachytherapy sources. The detector is based on an extremely fine suspension of monochloropentafluoroethane droplets emulsified in a gel. The droplets are highly superheated at room temperature and their evaporation can be triggered by photon(More)